RESUMO
Objective@#To study the status of antithrombotic therapy for ischemic stroke patients complicated with non-valvular atrial fibrillation(NVAF) in grass-roots hospitals, and to provide evidence for rational use of drugs in clinic.@*Methods@#From January 2018 to December 2018, the age, gender, previous history of stroke, history of atrial fibrillation, CHA2DS2-VASc score, HAS-BLED score and other clinical data of 102 ischemic stroke patients complicated with NVAF in the department of neurology of the Central Hospital of Songjiang District were retrospectively analyzed.The using of antithrombotic drugs and the international standardized ratio(INR) before and after hospitalization were also compared.@*Results@#The antithrombotic therapy of ischemic stroke combined with NVAF was mainly anti-platelet, accounting for 47.06%(48/102), and warfarin anticoagulation accounted for 33.33%(34/102). The initial dose of warfarin 1.25mg accounted for 90.32%(31/34), and the rate of INR reaching the standard(2.0~3.0) was low, accounting for 23.53%(24/102).@*Conclusion@#The antithrombotic status of patients with ischemic stroke complicated with NVAF in grass-roots hospitals is not ideal, and the utilization rate and standard rate of warfarin are low, which is not in accordance with the requirements of the guidelines.In view of this situation, clinical pharmacists can actively carry out anticoagulant management in conjunction with medical care, and work together to create a safe, effective and economical anticoagulant system for patients with atrial fibrillation.
RESUMO
Objective To study the status of antithrombotic therapy for ischemic stroke patients complicated with non-valvular atrial fibrillation (NVAF) in grass-roots hospitals,and to provide evidence for rational use of drugs in clinic.Methods From January 2018 to December 2018,the age,gender,previous history of stroke,history of atrial fibrillation,CHA2DS2-VASc score,HAS-BLED score and other clinical data of 102 ischemic stroke patients complicated with NVAF in the department of neurology of the Central Hospital of Songjiang District were retrospectively analyzed.The using of antithrombotic drugs and the international standardized ratio(INR) before and after hospitalization were also compared.Results The antithrombotic therapy of ischemic stroke combined with NVAF was mainly anti-platelet,accounting for 47.06％ (48/102),and warfarin anticoagulation accounted for 33.33％ (34/102).The initial dose of warfarin 1.25mg accounted for 90.32％ (31/34),and the rate of INR reaching the standard(2.0 ～ 3.0) was low,accounting for 23.53％ (24/102).Conclusion The antithrombotic status of patients with ischemic stroke complicated with NVAF in grass-roots hospitals is not ideal,and the utilization rate and standard rate of warfarin are low,which is not in accordance with the requirements of the guidelines.In view of this situation,clinical pharmacists can actively carry out anticoagulant management in conjunction with medical care,and work together to create a safe,effective and economical anticoagulant system for patients with atrial fibrillation.
RESUMO
OBJECTIVE:To compare the pharmacoeconomic efficacies of 5 drug therapeutic regimens for children pneumonia.METHODS:Using retrospective study and cost-effectiveness analysis to compare the pharmacoeconomic efficacies among the following 5 regimens in treating children pneumonia:amoxicillin sodium/clavulanate potassium(Group A),cefotaxime sodium(Group B),cefoperazone sodium/sulbactam sodium(Group C),cefuroxime sodium(Group D),and azithromycin(Group E).RESULTS:The effective rates of the 5 groups(A,B,C,D and E) were 80.43%,76.09%,65.12%,77.27%,and 91.30%,respectively,and the cost-effectiveness ratios were 1 595.06,1 225.38,1 669.69,1 284.83,and 697.84,respectively.CONCLU-SION:The regimen of azithromycin(group E) is the optimal one among the 5 groups for children pnemonia.