The Relationship between Expression of E-Cadherin, Clinical Staging and Differentiation in Squamous Cell Carcinomas of the Head and Neck / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: In recent years, much attention has been directed towards cell adhesion molecules. This study was designed to confirm the significance of E-cadhcrin as a marker for differentiation and invasiveness of squamous cell carcinomas of the head and neck. MATERIALS AND METHODS: Twenty-nine patients with squamous cell carcinoma of the head and neck were used in this study. The specimens of formalin-fixed paraffin-embedded tissues were investigated by immunohistochemical analysis using monoclonal anti-E-cadherin antibody. RESULTS: The results showed that here was a statistically significant correlation in the head and neck squamous cell carcinoma between the T and the N stage and the expression of E-cadherin (p=0.025, p=0.015). The cell differentiation was also correlated with the reduction of E-cadherin (p =0.005). CONCLUSION: E-cadherin may be linked to progression and differentiation of the head and neck squamous cell carcinoma. E-cadherin immunostaining in the primary tumor appear to be a good marker for the invasiveness and the metastasis of tumors.

Histopathologic Findings of Rabbit Cilia after Application of Radio Frequency Wave

As a modality of effective treatment for trichiasis, authors performed experimental study of the radio frequency application(Mehl's method) to the cilia of four rabbit eyes with the different application times(10, 30, 60, 180 seconds). For the control, electrolysis to the cilia of the two eyes, and two eyes without any application were observed histopathologically. Regardless of the radio frequency application time, the radio frequency applied eyelids did not reveal any gross changes, and the selective degenerative changes(pyknotic, vacuolar, and karyorrhaxis) were observed microscopically in the hair regeneration part(internal root sheath of hair, hair matrix, and papillae of hair). In the electrolysed eyelids, gross scar and severe necrotic changes were appeared in microscopic findings. As a result of our observation, it is indicated that the application of radio frequency as a treatment for trichiasis, in compare with the electrolysis, revealed less destructive to the adjacent tissue, with more selective changes on the portion for hair regeneration.