Study of Functional Magnetic Resonance Imaging at Resting State for Patients in Sub-health Status / 生物医学工程学杂志

This study sought to reveal the difference of brain functions at resting-state between subjects with sub-health and normal controls by using the functional magnetic resonance imaging (fMRI) technology. Resting-state fMRI scans were performed on 24 subjects of sub-health and on 24 healthy controls with gender, age and education matched with the sub-health persons. Compared to the healthy controls, the sub-health group showed significantly higher regional homogeneity (ReHo) in the left post-central gyrus and the right post-central gyrus. On the other hand, the sub-health group showed significantly lower ReHo in the left superior frontal gyrus, in the right anterior cingulated cortex and ventra anterior cingulate gyrus, in the left dorsolateral frontal gyrus, and in the right middle temporal gyrus. The Significant difference in ReHo suggests that the sub-health persons have abnormalities in certain brain regions. It is proved that its specific action and meaning deserves further assessment.

Contingent negative variation: a brainwave associated with expectation / 生物医学工程学杂志

The present study used the experimental patterns of Go/No Go and no motion contingent negative variation (CNV) task into the research in order to study whether the CNV can express the implication of expectation. Through comparing the CNV under different conditions, the data collected from experiment showed that the key to evoked CNV was close to the warning signal and command signal. Whether the command signal was related to the task would impact on the amplitude of the CNV. This characteristics responses to the subjects' expectation. On this basis, CNV can be used as the electrophysiological index for the reflection of expected value in the conditions of this experiment.

Correlation analysis between NOD2 gene single nucleotide polymorphisms and leprosy in Chinese Yi population / 中华皮肤科杂志

Objective To assess the association between NOD2 gene single nucleotide polymorphisms (SNPs) and leprosy in Chinese Yi population.Methods Whole blood samples were obtained from 300 patients with leprosy and 300 healthy human controls of Yi nationality in Sichuan province.Genomic DNA was extracted,and a SNaPshot assay was performed to determine the genotypes of four single nucleotide polymorphisms (SNPs) of the NOD2 gene,including rs9302752,rs7194886,rs8057341 and rs3135499.Chi-square test was conducted to compare allele frequency,and Hardy-Weinberg equilibrium was tested.Results The genotype distribution of all the four SNPs was consistent with Hardy-Weinberg equilibrium (all P ＞ 0.05).Significant differences were observed between the patients with leprosy and healthy controls in both genotype distribution and allele frequency of the SNP rs3135499 (both P ＜ 0.01),but not in those of the other three SNPs (all P ＞ 0.05).Conclusion The SNP rs3135499 of the NOD2 gene may be associated with the development of leprosy in Chinese Yi population.

Investigation of Depressive Status of Patients with HIV/AIDS and Their Family Members / 中华皮肤科杂志

Objective To understand the depressive status of patients with HIV/AIDS and their family members in order to provide objective information for conducting psychological interventions among them. Method The Self-rating Depression Scale (SDS) questionnaires were used for assessing the depressive status and the SPSS software was applied for data analysis. Results The SDS values among the patients with HIV/AIDS and the family members of died AIDS patients were significantly higher than those of healthy controls. The proportion of HIV/AIDS patients with medium to severe degree of depression was 15.5%, which was higher than that of healthy controls. The SDS values among female family members of HIV/AIDS patients were higher than those in male ones. Conclusion The depression is a negative psychological status usually occurred among the patients with HIV/AIDS and their family members, and the psychological interventions should be conducted based on the characteristics of different populations.