RESUMO
Objective:To summarize the clinical characteristics of drug-resistant epilepsy (DRE) in children and to analyze the efficacy of lamotrigine (LTG) add-on therapy for DRE in children of different seizure type, syndrome and etiological category.Methods:All cases of DRE patients treated with LTG or other antiseizure medication (ASM) adjunctive therapy in the Third Affiliated Hospital of Zhengzhou University from May 2019 to April 2020 were collected.The LTG add-on therapy group was treated with LTG add-on therapy, and the control group was treated with other ASM add-on therapy.The therapeutic effects of the two groups were compared.Results:A total of 134 cases meeting the requirement of research were collected, including 98 cases in the LTG add-on therapy group and 36 cases in the control group.For seizure of focal onset and unknown origin, there was statistical difference in efficacy between the LTG add-on therapy group and the control group ( Z=-2.48、-2.11, P<0.05), but for generalized DRE in children, there was no statistical difference in efficacy between the two groups ( Z=-0.39, P>0.05). There was a significantly statistical difference in curative effect between the LTG add-on therapy group and the control group for childhood DRE which could not be classified as any epileptic syndrome ( Z=-3.99, P<0.01), but there was no statistical difference in efficacy between the two groups for West syndrome and benign epilepsy accompanied by central temporal spikes ( Z=-0.94、-1.22, P>0.05). For childhood intractable epilepsy with unknown etiology, there was statistical difference in efficacy between the LTG add-on therapy group and the control group ( Z=-1.96, P<0.05), and for childhood intractable epilepsy with structural etiology, there was significantly statistical difference in efficacy between the two groups ( Z=-3.07, P<0.01), but there was no statistical difference in the efficacy for childhood intractable epilepsy with genetic etiology between the two groups ( Z=-1.02, P>0.05). Conclusion:The efficacy of LTG add-on therapy is significantly better than others for childhood DRE with seizure of focal onset or unknown origin, childhood DRE unclassified to any syndrome, and childhood DRE with structural etiology and unknown origin, especially with structural etiology.
RESUMO
BACKGROUND: Artificial total knee arthroplasty in the treatment of knee osteoarthritis can effectively eradicate the late knee pain, correct deformity, improve joint function, but the use of patel a is not conducive to the recovery, and it is easy to cause postoperative complications. Therefore, patel ar lateral shift, instead of patel a minimal y invasive therapy, has attracted more and more people’s attention, which increased excel ent and good rate of operation. OBJECTIVE: To investigate the effects of patel ar turnover and patel ar lateral displacement on knee function recovery and complications of elderly patients with total knee arthroplasty. METHODS: A total of 80 knees of 40 elderly patients with bilateral knee osteoarthritis were selected. Al patients according to the random number table method were divided into two groups with 40 knees of 20 cases in each group. The patients in the study group received patel ar lateral shift operation, while the patients in the control group received the patel ar turnover. Curative effects, the recovery of knee joint function and occurrence of complications were compared between the two groups at 1 week, 3 months, 6 months and 1 year after arthroplasty. RESULTS AND CONCLUSION: No significant difference in 90° flexion time in the knee was detected between the two groups after replacement (P > 0.05). Active straight leg raising time was shorter in the study group than in the control group (P 0.05). These results verified that patel ar lateral displacement for elderly patients with total knee arthroplasty is conducive to early knee function recovery after surgery, and it is safe and reliable.
RESUMO
After the concept of Chinese PLA digital hospitals was described , the current situations in information construction of both Chinese PLA hospitals and local hospitals were comparatively analyzed , which displayed the di-rection of information construction for Chinese PLA digital hospitals, and some measures that should be taken for the construction of Chinese PLA digital hospitals were proposed .