RESUMO
Werding-Hoffmann disease is a degenerative disease of motor neurons that begins in fetus and continues to be progressive in infancy and childhood. Most of them die by 2 years of age because of respiratory failure. The simplest and most accurate method of diagnosis is detection of serum genetic marker of SMA. In this article a neonate with Werding-Hoffmann disease is studied; the importance being that the disease was detected in his parents by DNA analysis. The two previous siblings died during infancy because of respiratory failure and muscular weakness. There was also a positive family history of an abortion during the second trimester; in other words an Autosomal Recessive [AR] disease affecting all of the 4 siblings. Werding-hoffmann is an AR disease with a rare familial incidence
RESUMO
With respect to the fact that the levels of prices and tariffs are determined out of the market procedure, the method of determination and estimation of a balanced price and the necessity of a transparent follow-up on outcomes of increased prices is of vital importance for the politicians of this section. To determine the effects of increasing hospital and medical services tariffs on price index in other economical sectors. In this applicable study, the input-output table of the year 2001 of the Iran Statistics Centres was used as the statistical basis. Using three scenarios associated with increased tariffs marked as "weak" [approved tariff], "moderate" [based on inflation rate], and "strong" [proposed by the Medical Council], the effects of increased tariffs on price index in other economical sectors were evaluated. Two open and close supply approaches were used to analyze the inputs. Findings: The first, second, and third scenarios in open approach for increase in tariffs indicated a range of effects on price index in economical sectors calculated at 0.00001-13.81%, 0.00001-15.31%, and 0.00003-50.43%, respectively. In closed approach, the increase in tariffs in the first, second, and third scenario showed a range of effects on price index in economical sectors calculated at 0.02- 12.46%, 0.02-14.01%, and 0.06-46.14%, respectively. Finally, the agricultural section demonstrated the least positive sensitivity and the hospital and medical section the most positive sensitivity to increase in tariffs. The findings of present study indicated that changes in medical and hospital services tariffs have little effects in other sections and a small role in production process and economic integration. These sections fundamentally have marginal consumption nature. The results of open and close approaches in different scenarios showed that the tariffs of medical and hospital sections must be increased according to the inflation rate. Keywords: Tariff, Price Index, Input-output
RESUMO
Background: Malaria is an acute and chronic illness characterized by paroxysms of fever, chills, sweating, fatigue, anemia, and splenomegaly. Most malarial deaths occur in infants and young children. Plasmodium falciparum causes the most severe form of malaria and is associated with more intense parasitemia. A manifestation of severe disease most common in young children includes cerebral malaria. Mortality rate of cerebral malaria is 20 to 40%. Malaria acquired in P. falciparum areas with known chloroquine resistance or where there is any malaria hotline should generally be treated with drugs other than chloroquine. In this paper we introduce a case of cerebral malaria from Zahedan/Iran
Case report: A 13-year old girl is presented with fever, jaundice, pallor and seizure. She was treated initially with chloroquine and premaquine. During treatment she developed convulsions with decreased level of consciousness. Suspecting chloroquine resistance this was substituted by quinine. After three days, she recovered completely and blood smear was free of parasites