RESUMO
Background: Nowadays, liver disorders are one of the most serious and threatening problems of the health. Persian Golpar [Heracleum [H.] persicum] as an endemic medicinal plant with antioxidant and anti-inflammatory properties was used [noted] in the study for reducing the live injuries
Objective: This experiment -for the first time- was conducted to consider the effects of the oils obtained from fruits of Persian Golpar on the liver toxicity induced by the injection of tetrachloride carbon [CCl4] in the Wistar rats
Methods: In this study, 100 male Wistar rats were divided into 20 groups [n=5]. Negative control group [NC] received DMSO and olive oil for two weeks and the positive control group [C] received DMSO as i.p injection in 14 days following CCl4 [2 ml/kg b.w] at day 15th. The standard group [BHT], The treatment groups received H. persicum essential oils at both doses 100 and 200 mg/kg b.w as i.p injection following CCl4 [2 ml/kg b.w] at day 15th. Then, the levels of the glutathione [GSH], total antioxidant capacity of plasma [FRAP], proxidasion lipids [MDA] and glutathione stransferase [GST] and also liver enzymes for instance alanin teransferase [ALT] and aspartate teransferase [AST] were estimated at 4, 8, 16 and 24 h after CCL4 injection
Results: The injection of the essential oils [at the both doses] obtained from Persian Golpar could surprisingly modulate the changes of the antioxidant/oxidative parameters as well as liver enzymes induced by CCL4 administration
Conclusion: These results indicated the protective effect of Iranian Golpar essential oils on the liver. These effects are probably due to its antioxidant capacity