RESUMO
<p><b>OBJECTIVE</b>To find out the mechanism of Tangfukang on the diabetic nephropathy(DN).</p><p><b>METHOD</b>A Model of streptorotocin diabetic rats was used. The expressions of the AGEs, ICAM-1, IV-C and FN were observed in renal cortex of diabetic rats with immunohistochemical method. The level of the IL-1 beta in blood serum was measured by radioimmunoassay method and the level of TNF was determined in blood serum by ELISA method. Aminoguanidine was selected as the control medicine which could inhibit the expression of monenzymatic glycosylation end products of protein. All the results were compared to analyze the effect of Tangfukang on monenzymatic glycosylation of protein and cytokine expression in early diabetic nephropathy rats.</p><p><b>RESULTS</b>Both Tangfukang and aminoguanidine significantly decreased the expression of AGEs, but Tangfukang was greatly superior to aminoguanidine in suppressing the expression of cytokine like ICAM-1, IL-1 beta, TNF-alpha and the ingredients of extracellular matrix like IV-C, FN.</p><p><b>CONCLUSION</b>It may be the partical mechanism of Tangfukang to suppress the monenzymatic glycosylation of protein and to reduce the expression of cytokine in diabetes. The effect of Tangfukang is superior to that of aminoguanidine.</p>
Assuntos
Animais , Masculino , Ratos , Córtex Suprarrenal , Metabolismo , Astragalus propinquus , Química , Cápsulas , Diabetes Mellitus Experimental , Metabolismo , Nefropatias Diabéticas , Metabolismo , Combinação de Medicamentos , Medicamentos de Ervas Chinesas , Farmacologia , Produtos Finais de Glicação Avançada , Metabolismo , Molécula 1 de Adesão Intercelular , Metabolismo , Interleucina-1 , Sangue , Ligustrum , Química , Phellodendron , Química , Plantas Medicinais , Química , Ratos Wistar , Fator de Necrose Tumoral alfa , MetabolismoRESUMO
Compressed oxygen in diaphragm-type compresesor currently used can easily cause fire,ex- plosion or damage.The reason for the causes was analysed and requirment for the oxygen was put forward. Proceed from the three aspect:selection of lubricating oil;replace of material quality and alarm for the di- aphragm broken;the problems of diaphragm-type compressor were finally settled.