RESUMO
Background: When the kidney is unable to filter blood, dialysis is an alternate method for filtration. Lifetime dialysis becomes unavoidable unless kidney transplantation is successfully done. Hemodialysis subjects normally have a poor quality of life and there is a positive association between quality of life of patient and support of family. Hence, it was necessary to conduct this study for creating awareness regarding the home management of dialysis among the caregivers of hemodialysis subjects to improve their knowledge. Objectives: The objectives of this study were as follows: (i) To assess the effectiveness of structured teaching programme (STP) on knowledge regarding home care management of hemodialysis subjects and (ii) to find association between pre-test knowledge and selected demographic variables. Materials and Methods: The evaluative approach was used; one group pre-test and post-test design was used. The study was conducted on sample of 40 caregivers of hemodialysis subjects using convenient sampling technique. The data were collected by structured questionnaire. The data were analyzed using descriptive and inferential statistics. Results: The mean knowledge score of caregivers of hemodialysis subjects during the pre-test was 39.48%, whereas it had risen up to 82.50% during the post-test as an effectiveness of STP. Therefore, the difference assessed was 43.02% between pre-test and post-test. Conclusion: There was significant difference between the pre-test knowledge level and post-test knowledge level of caregivers on home care management of hemodialysis subjects. Hence, health education programs and on-going teaching both can further improve the knowledge of caregivers.
RESUMO
Background: Maharashtrian population is at the risk of cervical cancer (CC) and is not subjected to investigate the cancer susceptibility in association with genetic determinants. Objectives: This study was aimed to evaluate the association of single nucleotide polymorphisms (SNPs) in DNA repair gene xeroderma pigmentosum complementation group D (XPD) with CC risk from rural Maharashtra. Materials and Methods: We used polymerase chain reaction and-restriction fragment length polymorphism to analyze SNPs in XPD gene from 350 patients with CC and 400 age and sex-matched disease-free controls. Results: The results indicated no significant difference in the genotype distribution between CC patients and controls for the XPD gene at codon 156 of exon 6 and codon 751 of exon 23, but the results showed that allele frequencies of XPD Asn 312 of codon 312 of exon 10 (odds ratio = 0.31; 95% confidence intervals = [0.16–0.63]; P = <0.001) genotype showed negative association with CC risk. Conclusion: This study indicated the role of XPD (cd312) in modifying genetic susceptibility of an individual to CC in Maharashtrian patients.