Comparative study of alkaline phosphatase and prostate specific antigen in prostate cancer.

The study comprised between healthy and benign controls and proven 62 cases of prostate cancer at different clinical stages. The mean value of increasing level of PSA in group III was found to be highly significant when compared with group I. Whereas, the mean value of elevated levels of ALP in stage III and IV from group III was found to be highly significant when compared with group I. Though the mean value of ALP was increased in stage I and II from group III when compared with group I, it was not found highly significant. Hence the elevated levels of ALP were significantly correlated with advanced stages of prostate cancer. Whereas, increased levels of PSA contribute to the diagnosis of potentially increased volume of the prostate cancer.

Subacute sclerosing panencephalitis in a case of aqueductal stenosis.

A 14-year-old boy presented with history of deterioration of scholastic performance, altered behaviour, difficulty in walking and repeated falls since last 2-3 months. He had history of delayed milestones and at 11 months developed febrile rashes. On investigations, MRI showed compensated hydrocephalus with aqueductal stenosis. EEG suggested subacute sclerosing panencephalitis (SSPE). CSF was positive for measles antibody titre. This case of aqueductal stenosis with SSPE is very interesting for its diagnostic dilemma.

Sociomedical correlates of missed opportunities for immunisation.

Missed opportunity for immunisation is one of the hurdles in the achievement of 85 percent or more immunisation coverage. It is essential to screen every child for immunisation status and advise necessary immunisation at every opportunity otherwise full immunisation coverage may not be possible. Present survey was carried out at Indira Gandhi Medical College and Hospital, Nagpur to study the sociomedical correlates of missed opportunities for immunisation in children below 2 years of age attending the hospital. Missed opportunities for immunisation in these children was found to be 39.9%. It is mostly for B. C. G. (21.8%) and measles (9.8%) and maximum for booster doses of DPT and polio (43%).

Sociomedical problems of institutionalised women.

The inmates of this institute form a special group in the society which is a reflection of various social pressures and problems. These institutionalised female largely come from poor socioeconomic families and often from families with serious social problems like family disharmony (30%), marital disharmony (20%), poverty (10%), unwedmotherhood (8%), broken homes (51.1%) etc. 90% inmates had one or more morbid conditions. Average number of morbid conditions per inmate was 2.16 at the time of study. Institution which assumes the custody of these women should provide them with medical services towards the rehabilitation and discharge of a healthy, productive, well adjusted citizens. An effective health education programme comprising of nutrition education, sex education, personal hygiene, alcohol and drug abuse should be specifically drafted and should be undertaken for the inmates.

Clinical significance and evaluation of proteinuria in NIDDM patients.

The proteinuria may reach massive proportions resulting in the nephrotic syndrome. Early and simple diagnostic may prevent further complications. Attempts are made to correlate a simple parameters like pH, specific gravity, excretion of reducing sugar and protein profile on SDS-PAGE, an advanced technique. The pH ranged between 5.7 to 9. However, specific gravity of the urine showed significant increase from 1.000 to 1.088 and has linear relation with percentage of sugar (0.2 to 2 gm) and protein banding 1 to 5 on SDS-PAGE.