RESUMO
Twenty-one patients with severe multiresistant gram-negative bacillary infections were treated with ciprofloxacin, intravenously followed by oral. The mean duration of therapy was 13 days. Causative organisms were Klebsiella pneumoniae (18 patients), Pseudomonas aeruginosa (2) and Salmonella enteritidis (1). The overall clinical improvement was 85 per cent, with a bacteriologic improvement of 90 per cent. Three patients died, one had fungemia, another had persistent bacteremia, and a third had progressive lung infiltration despite eradication of bacteremia. Superinfections occurred in 2 patients, and the other 2 had colonization of the wounds. It is shown that this treatment is effective and safe for the treatment of severe multiresistant gram-negative infections.
Assuntos
Administração Oral , Adolescente , Adulto , Ciprofloxacina/administração & dosagem , Resistência Microbiana a Medicamentos , Feminino , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Humanos , Infusões Intravenosas , Infecções por Klebsiella/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Infecções por Pseudomonas/tratamento farmacológico , Infecções por Salmonella/tratamento farmacológicoRESUMO
In a retrospective study 45 specimens of E. tarda infection from 44 adult cases at Songklanagarind Hospital during February 1982 to March 1989 were reviewed. There were 24 males and 20 females, with a mean age of 48.20 years. Nearly all of E. tarda were isolated from extraintestinal sources, especially pus and urine and most of them were subsequently found to be nosocomial-acquired infections. About half were polomicrobial infections of E. tarda and gram negative bacilli. Forty one patients were cured of the infection. Three cases died from bacteremia and serious underlying diseases.
Assuntos
Enterobacteriaceae/efeitos dos fármacos , Infecções por Enterobacteriaceae/microbiologia , Humanos , Testes de Sensibilidade Microbiana , Estudos Retrospectivos , TailândiaRESUMO
A young man recently responding to immunosuppressive therapy for acute myelocytic leukemia was admitted with fever and haemorrhagic blebs on both extremities after sustaining some scratch marks in a muddy pond. Gram stains of the hemorrhagic fluid in the blebs revealed many gram positive bacilli. B. cereus was identified from culture of tissue fluid. He did not respond to therapy despite bacteriological cure. Terminally, he developed Pseudomonas aeruginosa bacteremia and generalized bleeding.