RESUMO
One of the most commonly used antiepileptic drugs, phenytoin, has a narrow therapeutic index, high plasma protein binding, non-linearpharmacokinetics and inter-individual variability. It can also present with adverse drug reactions due to phenytoin toxicity with diverse presentations mimicking symptoms of other diseases thus causing diagnostic predicament. This case series reports three such cases of uncommon presentation of phenytoin toxicity like presenile cataract, fluctuating encephalopathy with diurnal variation and peripheral neuropathy. Monitoring of serum drug levels in such cases aids in confirming drug toxicity. Adverse drug reaction monitoring helps in early detection and appropriate management of drug related morbidity.
RESUMO
Background: To ascertain whether the pharmaceutical companies are following the WHO criteria for “Ethical medicinal drug promotion 1988” and “OPPI Code of pharmaceutical marketing practices, 2012” and to what extent. Also, to evaluate the therapeutic claims made by them in their drug promotional literature and other aspects.Methods: Drug Promotional Literature (DPL) from different pharmaceutical companies was collected from various Medical practitioners and analysed to see if they achieved objectives. Therapeutic claims made by them were classified as authentic, exaggerated, controversial, false, and misinterpreted.Results: Total 250 DPLs were collected and critically analysed for information content. Out of the 11 WHO criteria for ethical medicinal drug promotion (1988), Majority (30%) followed only 54.54% of the criteria while only 4% followed 100% of the criteria. The total number of claims in the 250 DPL were 354 of which 52.8% were authentic and 47.2% were misleading. From the misleading claims: 28.7% were exaggerated, 34.7% were controversial, 22.8% were false, 23% were ambiguous.Conclusions: This study enabled us to find out to what extent the pharmaceutical industries follow the standard criteria for DPL and evaluate the claims made by them. DPL is one of the important sources of drug information. Some of the pharmaceutical companies failed to follow the WHO criteria while advertising their products in order to make them look more lucrative having an underlying commercial motive. As they influence prescribing patterns of the clinicians, misleading promotional literature would result in irrational prescribing of drugs. To avoid this, DPL has to be critically evaluated.
RESUMO
OBJECTIVE: To obtain information on caries prevalence and treatment needs of children aged 5-10 years to plan appropriate dental care services in rural areas. MATERIALS AND METHODS: Children studying in all the primary schools (six schools) in the field practice area of the Rural Health Centre of the Faculty of Medicine, Annamalai University, Chidambaram, were surveyed. Each child was clinically examined in the schools by calibrated examiners. Dental caries was assessed using diagnostic criteria recommended by WHO (1997). The chi-square test and two-way analysis of variance were used for statistical analysis. RESULTS: Five hundred and eight 5-10 year-old school children (247 boys and 261 girls) were surveyed. Caries prevalence was 71.7 and 26.5% in primary and permanent dentition, respectively. The mean dmft and decayed missing filled tooth (DMFT) scores were 3.00 and 0.42 respectively. The mean dmft decreased with age ( P < 0.01) whereas the mean DMFT increased with age ( P < 0.001). Although the mean dmft scores were not statistically significant different for the two sexes, the mean DMFT score was found to be higher among girls than among boys ( P < 0.02). The entire dmft/DMFT value represented the 'decay' component only. There was a strong need for single surface restorations (60.6%). In the WHO index age (5-6 years), the caries prevalence was 70.2% (29.8% caries-free) with a mean dmft value of 3.54 +/- 3.71. CONCLUSION: Dental caries is a significant public health problem in this population. An extensive system to provide primary oral health care has to be developed in the rural areas of India.