RESUMO
@#Inhibition of xanthine oxidase (XO) activity is an effective therapeutic approach for the treatment of diseases such as goutand hyperuricemia. Additionally, the use of XO inhibitors can further be extended to injury treatments such as ischemicreperfusion in various organs such as heart, liver and kidney. In this study, 7 aurone compounds were synthesized andtested on XO and compared with the positive control allopurinol. Compound 5e was identified as the most potent compoundand was able to inhibit half of XO activity at 33.23 μM followed by compounds 5f and 5d at 210.22 μM and 302.0 μM,respectively. Finally, molecular docking study was conducted to understand the important binding interactions of theselected aurone with the active site of XO.