RESUMO
We assessed the iodine nutrition of upper socioeconomic strata school children from Delhi to identify its association with goiter, thyroid autoimmunity or thyroid function. After informed consent of parents, all assenting students (n=997) from one randomly selected section of each class from five private schools representing all the zones of Delhi) were evaluated for goiter, urinary iodine excretion, thyroid function and antibody status. Median urinary iodine was 35.28μg/dL. Goiter was present in 123 (12.3%) and positive anti-TPO antibodies in 17 (2.6%). Increased urinary iodine was associated with thyroid dysfunction, though not with goiter.
RESUMO
We report a young girl who presented to us with chest discomfort and had a paracardiac mass on chest radiograph. Computerised tomographic (CT) scan of the thorax was suggestive of pericardial cyst. Hydatid serology was negative. The cyst was excised.
Assuntos
Adolescente , Diagnóstico Diferencial , Equinococose Pulmonar/diagnóstico , Feminino , Humanos , Cisto Mediastínico/diagnósticoRESUMO
Neuropharmacological effects (Spontaneous locomotor activity, forced locomotor activity and anticonvulsant activity) of invermectin were studied at 400, 800 and 1600 micrograms/kg (administered, subcutaneously). Spontaneous locomotor activity was reduced at all the dose levels but forced locomotor activity was slightly reduced at 800 and 1600 micrograms/kg. The drug did not exhibit any anticonvulsant potential at any of the dose levels studied.
Assuntos
Animais , Anti-Helmínticos/farmacologia , Anticonvulsivantes/farmacologia , Comportamento Animal/efeitos dos fármacos , Sistema Nervoso Central/efeitos dos fármacos , Relação Dose-Resposta a Droga , Eletrochoque , Ivermectina/farmacologia , Masculino , Camundongos , Atividade Motora/efeitos dos fármacos , Tono Muscular/efeitos dos fármacosRESUMO
Cypermethrin a widely used insecticide of Pyrethroids (type II) group, was administered in mice at two dose levels (1/10 of LD50 i.e. 2.5 mg/kg and 1/5 of LD50 i.e. 5.0 mg/kg) and pharmacodynamic interactions of insecticide were studied with centrally acting drugs viz. pentobarbital sodium, amphetamine, pentylenetetrazole, acepromazine and analgin. Cypermethrin pretreatment potentiated the actions of pentobarbital and pentylene-tetrazole as evidenced by an increase in pentobarbital induced hypnosis and duration of pentylene-tetrazole induced chemoshock seizures. Tranquilizing action of acepromazine was potentiated but there was decrease in amphetamine influenced locomotor activity at both the dose levels. Cypermethrin pretreatment, however, did not have any pharmacodynamic interaction with analgin.