RESUMO
Background: Periodontal diseases are ubiquitous, affecting all dentate animals. Regular methods for controlling it have been found to be ineffective, which have paved the way for the use of herbal products as an adjunctive to mechanical therapy as they are free to untoward effects and hence can be used for a long period of time. Ocimum sanctum is a plant which has the greater medicinal value and enormous properties for curing and preventing disease. Objective: In the present study we assessed the effectiveness of Ocimum sanctum on dental plaque, gingival infl ammation and comparison with gold standard chlorhexidine and normal saline (placebo). Materials and Methods: A triple blind randomized control trial was conducted among volunteered medical students. They were randomly allocated into three study groups: (1) Ocimum sanctum mouthwash (n = 36); (2) Chlorhexidine (active control) (n = 36); (3) normal saline (negative control) (n = 36). Assessment was carried out according to plaque score and gingival score. Statistical analysis was carried out later to compare the effect of both mouthwash. ANOVA (Analysis of variance) and post-hoc LSD tests were performed using software package used for statistical analysis (SPSS) version 17. P ≤0.05 was considered as statistically signifi cant. Results: Our result showed that Ocimum sanctum mouthrinse is equally effective in reducing plaque and gingivitis as Chlorhexidine. The results demonstrated a signifi cant reduction in gingival bleeding and plaque indices in both groups over a period of 15 and 30 days as compared to control group. Conclusion: The results of the present study indicate that Ocimum sanctum mouthrinse may prove to be an effective mouthwash owing to its ability in decreasing periodontal indices by reducing plaque accumulation, gingival infl ammation and bleeding. It has no side effect as compared to chlorhexidine.
RESUMO
A study was conducted to evaluate the combined effect of Amlodipine and Simvastatin on the lipid levels of hypertensive obese patients. Amlodipine belongs to the dihydropyridine subclass of calcium antagonist whereas Simvastatin is a competitive inhibitor of HMG-CoA [3Hydroxy 3Methyl Glutaryl Coenzyme A] reductase. Three group of patients of both gender comprises 40 in each were included. Group A [hypertensive obese patients] was given amlodipine, group B [obese patients] was given simvastatin and group C [hypertensive obese patients] was given combination of amlodipine and simvastatin. Blood pressure was checked and tests for serum Cholesterol, serum Triglycerides and serum Lipoprotiens [HDL, LDL] was carried out by Standard kit methods [Merck]. The patients were evaluated three times i.e. before giving the medicines 0 week, at 6[th] and 12[th] week. The patients were advised to take fat free diet and a morning walk. Mean blood pressure of both male and female patients was significantly reduced. It was observed that combined therapy of Amlodipine and Simvastatin, significantly decreased the level of serum cholesterol, triglycerides and LDL-Cholesterol and significantly increased the level of HDL-Cholesterol in both sexes, but they did not show any significant synergistic effect as compared to the levels of these parameters in group A [amlodipine] as well as in group B [simvastatin]. A significant weight reduction is observed in male patients which may be due to low calorie diet and physical exercise. It is therefore concluded that synergism with Amlodipine and Simvastatin is not significant as the major action of Amlodipine is on blood pressure and the major effects of Simvastatin is on lipid profile and also reduced the body weight, if patients used calorie restricted diet with some morning walk