Beta-2 agonista como imunomodulador da resposta inflamatória oulmonar crônica induzida em camundongos awnaibilizados com ovoalbumina / B2-agonist as immunomodulator of chronic lung inflammatory response induced in mice sensitized with ovallbumin

Agonista de receptor b2-adrenérgico pode apresentar efeito imunomodulador. Estudamos a influência do salbutamol sobre a inflamação pulmonar crônica induzida por ovoalbumina em camundongos Balb/c, nos regimes a cada 96 horas (IS) e no regime diário (DS). Houve aumento expressivo de eosinófilos e neutrófilos no lavado broncoalveolar no modelo, a qual foi reduzida após DS. A OVA aumentou a quantidade de células LMN e EPO+ na parede de vias aéreas e no parênquima pulmonar / Beta2-adrenergic receptor agonist showed a imunomodulator effects. We study the influence of intermittent (IS) and diary (DS) regimen of salbutamol on ovalbumin induced chronic lung inflammation. Expressive increasing of eosinophils and neutrophils were observed in bronchoalveolar lavage from our model...

Comparison of knowledge on asthma: doctors completing internal medicine residency and doctors completing medical school

CONTEXT: Asthma has been reported as a disease of increasing prevalence. OBJECTIVE: To assess the level of information and knowledge about asthma by means of a questionnaire among recent graduate physicians applying for medical residency at the Clinical Hospital of the University of Säo Paulo Medical School, Brazil. DESIGN: 14 multiple-choice questions for asthma diagnosis and management. SETTING: University of Säo Paulo Medical School (FMUSP). PARTICIPANTS: Recent graduate physicians applying for the medical residency program at FMUSP in 1999 (n = 448) and physicians that had completed 2 year of internal medicine residency (n = 92). MAIN MEASUREMENTS: We applied a questionnaire with 14 multiple-choice questions about the management of asthma based upon the Expert Panel Report 2 - Guidelines for the Diagnosis and Management of Asthma, NIH/NHLBI, 1997 (EPR-2). RESULTS: The medical residency program in Internal Medicine improved treatment skills (the ability to propose adequate therapy) when compared to medical education (a score of 57.2 percent versus 46.9 percent, P < 0.001) but not diagnosis knowledge (understanding of asthma symptoms related to medicine intake) (33.5 percent versus 33.3 percent, P = 0.94). Treatment skills were higher among physicians who received their Medical Degree (MD) from public-sponsored medical schools in comparison with those from private schools [49.7 (SE 1.17)] versus [41.8 (SE 1.63)], P < 0.001. CONCLUSION: Medical schools might consider reevaluating their programs regarding asthma in order to improve medical assistance, especially when considering the general results for residents, as they were supposed to have achieved performance after completing this in-service training