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Asian Pac J Allergy Immunol ; 2000 Sep; 18(3): 173-6
Artigo em Inglês | IMSEAR | ID: sea-36955

RESUMO

Cholangiocarcinoma (CCA) constitutes carcinoma of the bile duct found at a high prevalence in northeastern Thailand. In the present study, we examined the sera of altogether 82 Thai CCA patients for the presence of anti-p53 antibodies in order to investigate a role of the tumor suppressor gene, p53 in the carcinogenesis. Our results revealed anti-p53 antibodies in 7.3% of the cases tested, which conforms to the prevalence rate of p53 gene mutation recently reported at 5% among Thai patients. With limited number of the patients, anti-p53 antibodies were rapidly detected more frequently among patients with peripheral tumors than those with central tumors. However, further studies is required to establish significance and prognostic value of the antibodies in the context of CCA.


Assuntos
Adulto , Idoso , Análise de Variância , Anticorpos Antinucleares/sangue , Anticorpos Antineoplásicos/sangue , Neoplasias dos Ductos Biliares/genética , Ductos Biliares Intra-Hepáticos , Colangiocarcinoma/genética , Ensaio de Imunoadsorção Enzimática , Feminino , Genes p53 , Humanos , Masculino , Pessoa de Meia-Idade , Mutação , Prevalência , Prognóstico , Estudos Retrospectivos , Albumina Sérica/metabolismo , Análise de Sobrevida , Proteína Supressora de Tumor p53/genética , alfa-Fetoproteínas/metabolismo
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