Biowaiver studies of newly optimized meloxicam tablets

In this research work biowaiver studies of newly developed and optimized Meloxicam 7.5mg and 15mg water dispersible formulations were carried out at different dissolution media i.e. 0.1N HCl, phosphate buffer pH 4.5, pH 6.8, and pH 7.5 at 50 rpm. For this purpose reference [MA[9] and MB[9] and tests MA[2], MA[4], MA[6], MA[7] and MA[8] [15 mg] and MB[2], MB[4], MB[6], MB[7]and MB8 [7.5 mg] formulations were compared. In vitro patterns were analyzed by using model-independent and model-dependent methods. Results indicated that all formulation at pH 0.1N HCl and phosphate buffer pH 4.5 followed Weibull model, while at pH 6.8 and pH 7.5 all formulations followed Hixson-Crowell model. Similarly results of model independent methods demonstrated that all the reference formulations were found to be similar with the tests formulations. Results indicated that Biowaiver could be granted to all the optimized water dispersible meloxicam formulations of both batches, so waiver for bioequivalence study can be allowed

Chlorpheniramine maleate: an effective antiallergic agent

Chlorpheniramine maleate is Hi receptor antagonist and is useful in the management of allergic and non-allergic rhinitis. It is commonly used to treat different symptoms associated with rhino conjunctivitis and urticaria. This article briefly reviews the therapeutic uses, drug-drug interactions, incompatibilities and side effects of chlorpheniramine maleate