RESUMO
Statement of the Problem: Various researchers have suggested the use of beta 2-adrenergic receptor antagonists in prevention or treatment of bone resorption
Purpose: This study aimed to evaluate the effect of beta 2-adrenergic receptor antagonists on number of osteoclasts and osteoblasts involved in the healing of extraction socket of maxillary first molar in rats
Materials and Method: Maxillary first molars of 40 rats were extracted and divided into two groups. The test group received 0.1 mg/kg propranolol intraperitoneally daily. The controls received normal saline. At days 7, 14, 21 and 28 post-extraction, 5 rats were euthanized from each group. Maxillary bone was resected and the mean number of osteoblasts and osteoclasts in tooth socket was measured
Results: After 1 week, the number of osteoclasts in the controls was significantly higher than the test group. A significant increase in the number of osteoclasts in both groups at week 1 was observed compared to the following weeks [p< 0.05]. The number of osteoblasts in the controls at second week reached its maximum rate but stayed constant in the 3[rd] and 4[th] weeks. Osteoblasts in the test group increased similar to the controls but reached its maximum at 3[rd] week and showed a significant increase compared to the controls [p< 0.05]
Conclusion: Beta 2 adrenergic receptor antagonists decrease the number of osteoclasts and increase the number of osteoblasts during extraction socket healing