Plasma protein variations in hemophiliacs receiving factor replacement therapy.

OBJECTIVE: Post transfusion manifestations and its affiliated factors are vital to understand in a disease like hemophilia where multi-transfusions are given to the patients. METHODS: To investigate the implications of factor replacement therapy on plasma proteins, 52 hemophiliacs and 68 carrier females were examined for 12 plasma proteins using various electrophoretic techniques. RESULTS: Severe hemophiliacs showed raised levels ( p< 0.05) of a2 M, IgG and Albumins where values were found to be 4.78 +/- 0.865 g/l, 21.48 +/- 3.38 g/l, 66.26 +/- 11.92 g/l respectively at 95% confidence intervals however, controls and carriers showed trivial variations. CONCLUSION: Juxtaposing the dissimilarities of 12 plasma proteins in carriers, controls and hemophiliacs, it has been gleaned that factor replacement therapy do play role when seen in severe hemophiliacs with raised levels.

Haemoglobin Variants In Some Ethnic Groups Of Punjab (North India).

A total of 1,312 blood samples were electrophoresed for haemoglobins using three buffer systems. The data comprised of 467 Jut Sikh, 271 Khatri, 355 Brahmins and 219 Banias. Ten cases of both slow and fast type of variant haemoglobins were observed Family studies conducted showed that eight of the variants were inherited in nature, whereas the remaining two were transient type.

Report Of Two Cases Of Alloalbuminemia.

Two inherited alloalbumins, designated albumin Ropar and albumin Samana were detected. The allele frequency for the variant albumins was found to be 0.0004 in the present study. These variant albumins were compared with some other previously reported alloalbumins