RESUMO
The ultimate goal of the treatment of wounds is to restore the damaged skin both structurally and functionally to its original state. Conventional treatment of chronic wounds does not seem to work in several cases, so it is necessary to develop different strategies. Recent research advances have shown the great potential of cell-based therapies in improving the pace and quality of wound healing and skin regeneration. Cell-based therapy is thus considered a new alternative to classic methods of wound healing. This review seeks to give an updated overview of the applications of cell-based therapy in wound management. Even though cell therapy is a relatively new tool, several studies prove these types of cells can be used safely, and they have demonstrated their efficacy in healing wounds in several cases.
RESUMO
Development of perilobular hepatic fibrosis in rabbits after experimental ligation of the common bile duct was studied by microscopy. Twelve hours after the ligation, the lobular boundaries assumed prominence by appearance of row(s) of congested sinusoids around the distended perilobular canals of Hering. Seven days later, the lobular laminae limitans around such canals of Hering revealed myxomatous ballooning degeneration forming well defined inter-lobular bands (ILBs). On day 15 post-ligation, the residual sinusoidal endothelial-lining cells in the ILBs manifested hyper chromasia and occasional mitotic activity. It was followed, on days 25 and 35, by proliferation (hyperplasia) of the sinusoidal endothelium cells forming the portal tract like fibrotic tissue in the perilobular bands. These findings, showed the course of interlobular bridging necrosis along the bile preductules at the lobular circumferences and subsequently indigenous origin of the fibrotic tissue in the ILBs from the residual cells in the affected parenchyma independent of the portal tracts.