RESUMO
Background: Seasonal fluctuation in incidence of invasive pneumococcal disease, pulmonary embolism, deep vein thrombosis and coronary heart disease etc has been reported since long time. So, the present study was conducted to evaluate the seasonal variation in hematological and hemodynamic parameters, heart rate and blood pressure in the month of November, February and May. Materials and methods: 15 male subjects in the age group of 18.5±1 year were matched on haematological parameters, heart rate and blood pressure in three different seasons and the results were compared. Results: Packed cell volume in winter (February), Erythrocyte Sedimentation Rate in summer (May) were increased (P< 0.001) as compared to basal level in November month with non significant variation in Hemoglobin concentration and Red Blood Cell count. Total Leukocyte count significantly increased (p <0.001) in winter, while on differential and absolute leukocyte count Eosinophil, Basophil, Monocyte, Lymphocyte (%) were elevated (p <0.001) and Neutrophil (%) decreased (p <0.001) in summer. Total Protein concentration, serum Albumin level was higher in winter. Heart rate shows insignificant seasonal changes but blood pressure, both systolic and diastolic was lower (p< 0.001) in summer and rate pressure product (RPP) was higher (p<0.05) in winter. Conclusion: So, these findings indicate that variations in different parameters do occur to adapt to the environmental conditions which may be responsible for susceptibility to different diseases e.g. asthma and ischemic heart diseases in different seasons.
RESUMO
Background: Cervical spondylosis is a common progressive degenerative disorder of the human spine often caused by the natural aging process. Osteophytic formations contribute to biomechanical changes that result in neural and vascular compression. The spinal compression of the obliquely passing cervical nerve roots can result in possible autonomic imbalance in the body. Valsalva maneuver is a simple, non-invasive and cost effective means to assess the autonomic activity. The results are appreciably reproducible if done properly under standardized conditions. Valsalva ratio is an important index of the baroreflex-mediated bradycardia and gives a fair idea about the parasympathetic tone. Aim: The aim of our study was to assess the level of autonomic activity by studying the valsalva ratio in patients with cervical spondylosis and to compare it with healthy controls. Materials and methods: This prospective random case control study was conducted at Pt. B. D. Sharma PGIMS, Rohtak. The study sample comprised of group I consisting of thirty randomly selected age and sex matched healthy controls and group II of thirty patients diagnosed with cervical spondylosis (age group 30-60 years of either sex). Results: In our study, valsalva ratio was found to be significantly low (p<0.01) in patients of cervical spondylosis as compared to healthy individuals. Conclusion: Altered parasympathetic tone can predispose the patients to hemodynamic instability leading to adverse cardiovascular implications in the long run.