RESUMO
Disabling pansclerotic morphoea of childhood is a subset of localized scleroderma. It is a rare disease in both the adult and paediatric population. E t i o l ogical factors are unknown although autoimmune, infectious, genetic and environmental factors have been postulated. Sclerotic plaques predominantly affect the scalp, face, trunk and extensor surfaces of limbs, leaving fingertips and toes uninvo l ved. The absence of Raynaud’s phenomenon, dysphagia, visceral involvement and certain laboratory derangements diff e r e n t i a t e systemic sclerosis and disabling pansclerotic morphoea of childhood. Diagnosis can be supported by histology. There are seve r a l management options including topical, systemic and phototherapy.
RESUMO
Fusarium species are common plant pathogens present in the environment but can cause invasive infections in immunocompromised patients, especially those with haematologic malignancies and bone marrow transplant recipients1. Tissue and blood cultures are especially important as they offer a high diagnostic yield in invasive fusariosis2-3. Amphotericin B has been used as the mainstay of treatment4 although resistant rates are high, especially in Fusarium solani species5. The treatment outcome is also closely related to rate of recovery of neutropenia