RESUMO
Hyperviscous semen is an etiologic cause for male-related infertility which is related to function of oxidative systems in the cells. So, use of anti-oxidants may be useful. Hence, this study was conducted to evaluate the efficacy of N-acetyl-l-cysteine in reduction of seminal viscosity. In this experimental study, 200 patients attending to urology clinic of Amiralmomenin hospital with hyperviscouse semen were selected and treated with N-acetyl-l-cysteine, 500 mg twice a day for one month. Sperm analysis was repeated after treatment and 10 days later. After treatment, the viscosity which was initially high in all patients was normal in 124 men [62%], high in 60 patients [30%], and low in 16 subjects [8%]. Also sperm count, motility, and morphology were improved significantly after the treatment [p< 0.05]. According to 70 percent efficacy for Nacetyl-l-cysteine and lack of any drug adverse effects, this therapeutic modality may be indicated upon with patient's conditions and physician's opinion