Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism / 대한해부학회지

The role of androgens in the development of cardiovascular diseases remains controversial. The current study therefore sought to determine the changes in the histomorphology of the common carotid artery of the male rat in orchidectomy-induced hypogonadism. Twenty-two Rattus norvegicus male rats aged 2 months were used. The rats were randomly assigned into baseline (n=4), experimental (n=9), and control (n=9) groups. Hypogonadism was surgically induced in the experimental group by bilateral orchiectomy under local anesthesia. At experiment weeks 3, 6, and 9, three rats from each group (experimental and control) were euthanized, their common carotid artery harvested, and routine processing was done for paraffin embedding, sectioning, and staining. The photomicrographs were taken using a digital photomicroscope for morphometric analysis. Orchidectomy resulted in the development of vascular fibrosis, with a significant increase in collagen fiber density and decrease in smooth muscle and elastic fiber density. Moreover, there was development of intimal hyperplasia, with fragmentation of medial elastic lamellae in the common carotid artery of the castrated rats. Orchidectomy induces adverse changes in structure of the common carotid artery of the male rat. These changes may impair vascular function, therefore constituting a possible structural basis for the higher incidences of cardiovascular diseases observed in hypogonadism.

Pedagogical value of dissection anatomy in Kenya

Anatomy has historically been a cornerstone in medical education regardless of nation or specialty. Revolution in the training of anatomy has been based on the lack of adequate instructors, cadavers and the general high cost of anatomy training. This has led to the abandonment of dissection by most countries in favour of other methods of learning. At the University of Nairobi, the need for more instructors has been addressed by training anatomists and by incorporating surgical resident students in the training of undergraduate medical students. The catchment of collecting cadavers has been increased to address the need for cadavers, with increased competition for this resource from other medical schools in Kenya. This article shares our experience at the Department of Human Anatomy, University of Nairobi, and presents arguments for the dissection course as a central tool for teaching macroscopic anatomy.