[Pseudo tumoral gastric amyloidosis: about a rare case report]

Amyloidosis is an abnormal extracellular deposition of insoluble proteins, which is associated with an involvement of the gastrointestinal tract in 50 to 70% of cases. In primary amyloidosis [light chain amyloidosis], localized gastric involvement is a rare finding which can mimick malignancy. To elucidate the clinical, histological and therapeutic features of pseudo tumoral gastric amyloidosis via a rare report along with a review of related literatures. We report the case of 56-year -old man, admitted with upper digestive outlet obstruction. Linitis plastica with lymph node involvement was suspected by gastroscopy, barium meal and endoscopic ultrasonography but was not confirmed by gastric biopsies. The patient was treated with total gastrectomy with lymph node dissection. Pathological examination demonstrated gastric and lymph nodes amyloidosis and no malignant tumor was found. We propose that amyloidosis should be considered in the differential diagnosis of gastric tumors

[Descriptive epidemiology of extrapulmonary hydatid cysts: a report of 265 Tunisian cases]

Hydatidosis is a parasitic endemic disease in Tunisia. The liver and lung are the most common sites of involvement; however, it can develop anywhere in the body. The aim of the present study was to analyse the epidemiological features of extrapulmonary hydatid cysts and compare our results with those reported in literature. Aretrospective study of 265 extrapulmonary hydatid cysts collected over the 18-year period from 1990 to 2007 was undertaken. There were 101 male and 164 female patients [sex ratio M/F= 0, 61] ranging in age from 2 to 84 years [mean age = 38, 7]. In our series, hydatid cysts involved mainly the kidney [24, 1%], the central nervous system [22, 6%], the liver [19, 6%] and the spleen [11, 3%]. The other less frequent sites included the peritoneum [n = 9], heart [n = 9], bone [n = 6], adrenal gland [n = 4], epiploon [n = 4], orbit [n = 4], ovary [n = 3], prostate [n = 2], bladder [n = 2], breast [n = 2], Douglas' cul-de-sac [n = 2], diaphragm [n = 1], testis [n = 1], broad ligament [n =1], mediastinum [n = 1], nasal cavity [n = 1], soft tissue [n = 1], abdominal wall [n = 1], parotid gland [n = 1], psoas muscle [n =1], synovia [n = 1], thymus [n =1] et le pancreas [n = 1]. In contrast to literature, our results show that hydatid cysts of the kidney and of the central nervous system are more frequent than hepatic location which occupies the 3rd rank

[Carcinosarcoma of the urinary bladder. Report of three cases]

Carcinosarcoma of the urinary bladder is a very rare neoplasm accounting for less than 0, 05%of urothelial tumours is a biphasic malignant neoplasm with only 79 cases reported in the English literature. Histologicaly, it exhibits morphologic and/or immunohitochemical evidence of epithelial and mesenchymal differenciation with the presence or absence of heterologous elements. It usually involves aged adults after 60 years and it has a poor prognosis. We report three cases with an emphasis on unusual histologic features. Three male patients age 76 to 86 years were found to have polypoide masses in the urinary bladder. In all cases, microscopic examination revealed biphasic neoplasms with distinct mesenchymal and epithelial components. The two first cases were remarkable respectively by the presence of chondrosarcomasrcomatous and osteosracomatous components

Salivary gland biopsy: experience of La Rabta Hospital's pathology department

The minor salivary gl and s biopsy is a very common diagnostic procedure in oral medicine rather its efficiency has not been statistically proved. Assessment of Rabta pathologic department experience. 297 biopsies have been studied with special attention to the suspected diagnosis before biopsy and the final histologic result. The minor salivary gl and biopsy confirmed the initial diagnosis in 78 cases. Although if the minor salivary gl and biopsy is in most cases not contributively, it is a very simple procedure which gives the diagnosis of Gougerot-Sjogren disease, amylosis and sarcoidosis

[Gastrointestinal stromal tumor: epidemiology and outcome study in 40 cases]

The aim of this study was to analyze epidemiology and outcome of 40 patients with gastrointestinal stromal tumor [GIST] expressed CD117. All epidemiological data [age, sex, location] and survival data were analyzed retrospectively. The tumors occurred in 17 men and 23 women. Stomach was the most common site of localization [47.5%]. Of the 37 patients without Gleevec treatment, 18 benign cases [66.6%] showed long-term survival [2 to 8 years] and 9 malignant cases [33.3%] were diagnosed. 10 cases were still being in followed [< 2 years]. Gastric tumor's survival was better than extragastric tumor's survival without statistically significance [p>0.05]. Our experience confirms that GIST is an aggressive tumor. 33.33% of them are malignant with recurrence or metastatic potential. Additionally, epidemiologic factors [age, sex and location] do not have a predictive value

Teratome kystique mature de la trompe a propos d'une observation

Primary teratomas of the fallopian tube are extremely uncommon. Only about 50 cases have been reported in the literature. They occur usually in the fourth decade. There association with nulliparity and reduced parity has been noted. Many have been discovered incidentally and none has been diagnosed preoperatively. The majority are cystic, show great variation in size and are commonly located in the ampulla or the isthmus. They can be intraluminal, attached to the serous surface by a pedicule and rarely intramural. Histologically they are similar to teratoma of the ovary and elsewhere. We describe a mature cystic teratoma of the fallopian tube found incidentally in a 35-year-old woman operated for suspicion of ectopic tubal pregnancy. The feature of benign teratoma of the fallopian tube is discussed

[CD117 contribution in the diagnosis of mesenchymal tumors of the digestive tract]

Gastrointestinal stromal tumor [GIST] is a new distinct entity defined as CD117 or c-kit positive mesenchymal tumors, originaling in gastrointestinal pacemaker cells known as interstitial cells of Cajal. This study evaluate the percentage of GIST previously diagnosed as mesenchymal tumors in our hospital during 11 years. A total of 30 surgically resected gastrointestinal tumor specimens were collected from January 1990 to December 2000 in the pathology laboratory of La Rabta Jospital. Immunohistochemical studies were performed on these tumors with antibodies of CDI 17, smooth muscle actin [SMA] and protein S-100. Among the 30 tumors, 26 [86.6%] were CD117 positive and were classified as gastrointestinal stromal tumors. Among the 26 GIST, SMA was positive in 11 tumors [42.3%], 6 tumors [23%] expressed protein S- 100. The 4 tumors classified as non-GIST were leiomyomas with the following immunohistochemical characteristics: CD117-negative with strong SMA-positive and protein S100 negative status. The majority [86.6%] of mesenchymal gastrointestinal tumors were GIST, except for a smalls groups of smooth muscle tumors

Tumeur stromale sclerosante de l'ovaire. A propos de 3 observations

Sclerosing stromal tumor [SST] is an uncommon benign tumor of the ovary, distinct from thecoma and fibroma because of predominant occurrence below 30 years of age, lack of hormonal manifestations and histologic heterogenity. Three cases of SST occurring in a 15, 26 and 56-year old females are reported review of the literature and clinicopathological features are described in the present article. Histogenesis and differential diagnosis are also discussed