Histopathological alterations of tissue adjacent DMBA-induced premalignancy following a radiowave diathermy intervension

Leukoplakia like lesion was induced in hamster buccal pouch mucosa utilizing DMBA and subsequently removed using different methods including radiowave diathermy. Histologic changes of the surrounding tissue was examined after 10 weeks period. Although malignant transformation was shown to develop as a result of effect of radiowave diathermy interference, lack of tumor potentiating was recorded