Assessment of respiratory muscles endurance in diabetic patients

Respiratory muscle endurance is of interest in pulmonary, critical care and many other areas of medicine. The maximal voluntary ventilation [MVV] test is an objective dynamic method for measuring the working capacity of respiratory muscles. Therefore, we designed the present study to determine the effect imposed by diabetes mellitus on respiratory muscle endurance in Saudi diabetic patients. We conducted this study in the Department of Physiology, College of Medicine, King Khalid University Hospital and Diabetic Centre, King Abdul-Aziz University Hospital, Riyadh, Saudi Arabia during the year 2002-2004. In this study, we recruited 39 male diabetic patients and equal number of control subjects and all participants were non-smokers with age range of 23-71 years. The subjects were matched for age, height and weight. We determined the respiratory muscles endurance by a direct MVV test during inspiratory and expiratory phases of respiration by using a MP-100 student Bio Pac system and compared the results using a paired t-test. In inspiratory and expiratory phases of respiration, diabetic patients showed a significant reduction in the mean values of direct MVV test [p<0.001] relative to their matched controls. We conclude that in diabetic patients the respiratory muscles endurance is impaired by a decreased in MVV values. This decline in MVV further showed that the diabetic patients have a reduced inhaled and exhaled volumes during consecutive breaths

Lung function in type 2 Saudi diabetic patients

To study the effects of type 2 diabetes mellitus on lung function and to determine its severity in relation to duration of disease. We conducted this study in the Department of Physiology, College of Medicine, King Khalid University Hospital and Diabetic Centre, King Abdul-Aziz University Hospital, Riyadh, Saudi Arabia during the year 2002 -2004. A group of 32 apparently healthy volunteer male type 2 diabetic patients were randomly selected with an age range from 24-73 years. We matched the diabetic patients with another group of 40 control healthy male subjects in terms of age, height, weight, and socioeconomic status. Both groups met with exclusion criteria as per standard. Spirometry was performed on an Electronic Spirometer [Schiller AT-2 Plus, Switzerland] and results were compared using the 2-tailed student t-test. Diabetic patients showed a significant reduction in the forced vital capacity [FVC], forced expiratory volume in one second [FEV1] and peak expiratory flow [PEF] relative to their matched controls. However, there were no significant difference in the forced expiratory ratio [FEV1/FVC%] and middle half of the FVC [FEF 25-75%] between the groups. Lung function in type 2 diabetic patients is impaired by a decrease in FVC, FEV1 and PEF, as compared to their matched controls. Stratification of results by years of disease showed a dose-response effect on lung function

Lung function in type 1 Saudi diabetic patients

To determine the effects of type 1 diabetes mellitus on lung function and its gravity in relation to the duration of disease. We carried out this study in the Department of Physiology, College of Medicine and Diabetic Center, King Abdul-Aziz University Hospital, King Saud University, Riyadh, Saudi Arabia during the period 2003-2004. We randomly selected a group of 27 apparently healthy volunteer Saudi male type 1 diabetic patients with age ranging from 19-70 years. We matched the diabetic patients with another group of 27 control healthy male subjects in terms of age, height, weight and socioeconomic status. Both groups met with exclusion criteria as per standard. We performed spirometry on an Electronic Spirometer [Schiller AT-2 Plus, Switzerland] and compared the results by a student t-test [2-tailed]. Type 1 diabetic patients showed a significant reduction in the forced vital capacity and forced expiratory volume in one second [FEV1] relative to their matched controls. However, there was no significant difference in the forced expiratory ratio, forced expiratory flow; forced expiratory flow and peak expiratory flow [PEF] between the groups. It is concluded that lung function in type 1 diabetic patients is impaired by a decrease in FVC and FEV1 as compared to their matched controls. Additionally, the years of disease showed a dose-response effect on lung function