RESUMO
OBJECTIVE: To determine the efficacy of Nepafenac 0.1% eye drops in maintaining mydriasis during phacoemulsification cataract surgery
METHODS: Patients of 40 - 65 years of age undergoing phacoemulsificaton cataract surgery were randomly divided into two groups. One group received Nepafenac 0.1% eye drops and the other group received placebo [Tears Naturale II eye drops]. Pre - operatively; all patients received tropicamide 1% eye drops and phenylephrine 2.5% eye drops
The surgery in all the cases was done by the same ophthalmologist; with intra - operative epinephrine in the irrigating solution. The pupil size was measured with caliper at three steps; immediately before the surgical incision [baseline], at the end of phacoemulsification, and at the end of surgery
RESULTS: 60 eyes of 60 patients were included in the study. 30 eyes were in the Nepafenac 0.1% group and another 30 in the placebo group. The mean age of our patients was 54.18 +/- 7.49 years. The mean diameter of pupil at end of surgery was 7.65 +/- 0.71 mm in Nepafenac group V/s 6.67 +/- 0.97 mm in the placebo group [P- Value < 0.001]
In the Nepafenac group; the pupil size at the end of surgery decreased by a mean of 0.55 +/- 0.51 mm [range 0.00 - 1.50 mm]. Meanwhile; in placebo group the pupil size decreased by a mean of 1.05 +/- 0.87 mm [range 0.00 - 3.5 mm]. This difference was statistically significant [P = 0.009]
CONCLUSION: The pre - operative use of Nepafenac 0.1% eye drops was effective in maintaining mydriasis during phacoemulsification cataract surgery