RESUMO
To assess the effect of the 5-days intensive diabetes health education program on metabolic control among Saudi type 2 diabetic patients. The study included 438 individuals, 158[36.1%] females and 280[63.9%] males with type 2 diabetes. All patients completed the 5-days diabetes education program. They did not require any change in their current therapy regimen, had not previously participated in any diabetes education programs, Saudi patients, of both genders, non-pregnant and older than 30 years. They were followed for one year after attending a 5-days structured education program conducted at University Diabetes Center in Riyadh, Saudi Arabia. Data were collected for each individual before attending the program, three months later, and one year after completion of the program. After one year, all metabolic parameters had improved significantly [P<0.0001] except for high density lipoprotein[HDL] [P =0.097] as follows: body weight [mean +/- SD] 78.72 +/- 13.77 to 78.11 +/- 13.33 Kg; systolic blood pressure 137.69 +/- 15.56 to 129.5 +/- 15.09 mmHg; diastolic blood pressure 77.27 +/- 8.11 to 72.9 +/- 7.30 mmHg; fasting blood sugar 10 +/- 2.62 to 8.19 +/- 2.04 mmol/l; HbA1c 8.78% +/- 1.78% to 7.87% +/- 1.56% ; triglycerides 1.98 +/- 0.9 to 1.51 +/- 0.67 mmol/l; total cholesterol 4.77 +/- 0.83 to 3.9 +/- 0.83mmol/l; low density lipoprotein 2.71 +/- 0.66 to 2.15 +/- 0.59mmol/l, and high density lipoprotein improved by an increase from 1.28 +/- 0.4 to 1.31 +/- 0.24 mmol/l. This study demonstrates that intensive education program provided by a trained professional healthcare team is an effective approach and reinforces the need for implementing such education program as an essential part for metabolic control among diabetic patients.
RESUMO
To determine whether clinical and biochemical features of Graves' disease at presentation predict response to medical and radioiodine treatment. We carried out a retrospective 10-year study of 194 consecutive Saudi subjects with Graves' disease who were treated with antithyroid drugs, radioiodine therapy, or both, between January 1995 and December 2004 at King Khalid University Hospital, Riyadh, Saudi Arabia. At diagnosis, the mean age was 32 +/- 0.9 years. Only 26% of patients had successful outcome after a course of antithyroid medication. None of the clinical or biochemical factors were associated with a favorable outcome of antithyroid treatment. One dose of radioiodine [13-15 mCi [481-555 MBq]] cured hyperthyroidism in 83% of patients. Presence of ophthalmopathy at presentation was shown to be a significant contributing factor to failure to respond to a single dose of radioiodine [odds ratio, 6.4; 95% CI, 1.51-24.4; p<0.01]. Failure of radioiodine treatment was also associated with higher serum free T3 concentration at presentation [p=0.003]. In patients with Graves' hyperthyroidism, radioiodine treatment is associated with higher success rate than antithyroid drugs. A dose of 13-15 mCi [481-555 MBq] seems to be practical and effective, and should be considered as first line therapy. Patients with high free T3 concentration and, those with ophthalmopathy at presentation were more likely to fail radioiodine treatment. A higher dose of radioiodine may be advisable in such patients