RESUMO
To determine the accuracy of antepartum Amniotic Fluid Index [AFI] of = 5 cm as a predictor of adverse outcome at birth in high-risk pregnancies. Cross-sectional study. Obstetrics and Gynaecology Unit I, Holy Family Hospital and Railway Teaching Hospital Complex, Rawalpindi, from February 2003 to January 2004. One hundred pregnant women at term gestation were studied. Each high-risk woman at term with an AFI of < 5 cm admitted for delivery through emergency or outpatient department was labeled as predictor of poor outcome. The next high-risk pregnant woman at term with the same pregnancy complication but an AFI of > 5 cm was labeled as predictor of good outcome at birth. The subjects in both the groups were demographically matched and fulfilled the inclusion and exclusion criteria. The Apgar score was calculated at 5 minutes of birth. The newborns, with Apgar score = 6 at 5 minutes of birth were labeled as diseased and > 6 were labeled as healthy. AFI was compared with Apgar score, using Chi-square and a p-value was calculated to determine the statistical significance. Sensitivity, specificity, efficiency and the predictive values of AFI at a cut off point of = 5 cm as a predictor of adverse outcome at birth [Apgar score of = 6 at 5 minutes of birth] in high-risk pregnancy were calculated. Only 8 neonates of 50 women with low AFI had low Apgar score. Similarly, 6 neonates of 50 women with normal AFI had poor Apgar score. The diagnostic sensitivity, specificity, positive predictive value, negative predictive value and efficiency of AFI as test were 57.1%, 51.3%, 16%, 88% and 52% respectively. Low AFI is a poor predictor of adverse outcome for high-risk term patients. AFI is not a good screening test for high-risk pregnant women at term for birth of an infant with low Apgar score
Assuntos
Humanos , Feminino , Líquido Amniótico , Índice de Apgar , Estudos Transversais , Recém-Nascido , Sensibilidade e Especificidade , Valor Preditivo dos Testes , Paridade , Parto Obstétrico/métodos , Resultado da Gravidez , Diagnóstico Pré-Natal , Oligo-Hidrâmnio/diagnósticoRESUMO
To evaluate various histo-pathological features in endometrial curettings of patients complaining of menstrual irregularities with excessive blood loss and correlating them with clinical presentations. A total of 260 endometrial curettings were obtained by Dilatation and Curettage done at the Department of Gynecology and Obstetrics, Railway Hospital, Rawalpindi. All the preserved specimens were processed under standard conditions at the Pathology Department, Islamic International Medical College [IIMC]. The sections were studied after staining with Haematoxylin and Eosin stain. The patients presented with menorrhagia in 51.9%, metrorrhagia in 35.4%, polymenorrhoea in 9.2% and polymenorrhagia in 3.5% cases. History of hormonal intake was observed in 0.66% patients. Menstrual disorders were most common in 41-50 years age group accounting for 48% cases. Pathology was diagnosed in 40% of endometrial biopsies. The endometrial lesions included endometrial hyperplasia [24.7%], chronic nonspecific endometritis [13%], endometrial polyp [1.2%], pill pattern endometrium [2.3%] atrophic endometrium [0.8%] menopausal pattern endometrium, squamous metaplasia, squamous cell carcinoma and chorioncarcinoma [0.4% each]. The dilatation and curettage was found to be an appropriate approach with a good diagnostic yield. Fortunately frequency of endometrial malignancy appeared to be very low. Endometrial hyperplasia was the leading causes of excessive menstrual bleeding