RESUMO
Comparative study of two types of chemically-induced diabetes was performed. Twenty four male rats were divided into three equal groups : Control, alloxan, and streptozotocin [STZ] treated groups. Investigation of the differences in lipid patterns after I.V. injection of either alloxan monohydrate or STZ was done. Results obtained revealed a harmful effect of both drugs in male rats. However, it was more severe in the STZ group. Both of the two compounds produced hyperglycemia which showed no significant differences between the two groups [Alloxan and STZ]. There was significant increase in the serum cholesterol level after STZ. Significant increase in serum triglyceride levels after both drugs. Cholesterol was mainly incorporated in the VLDL in the STZ group and in the LDL in alloxan group. A linear positive correlation between serum F.F.A. and blood glucose levels was found in both types of chemically-induced diabetes which was significant in STZ group but insignificant in the alloxan group. In case of insulin-dependent diabetics, and patients under the anti-tumour drug streptozotocin attention should be directed and the above results should be considered as regards the possible harmful effects on the lipid pattern, and hyperglycemia