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1.
Artigo em Inglês | IMSEAR | ID: sea-154156

RESUMO

Background: To study drug utilization of anticancer drugs in cancer outpatient department (OPD) of Government Medical College, Aurangabad. Methods: Five hundred and twelve prescription records were screened and analyzed as per the study parameters from cancer OPD of Government Medical College and Hospital, Aurangabad. Commonly used anticancer drugs were recorded; furthermore, different types of carcinomas were noted. Results: Age group of patients was in between 30 and 70, 267 were females and 245 were male patients. The most common type of carcinoma was carcinoma of the breast (17.9%). Carboplatin was the most commonly used anticancer drug (26.56%). The average number of anticancer drugs received per patient was three. Conclusion: WHO suggested drug utilization studies are needed in every health care setting. For a developing country like India, National Drug Policy and Drugs and Therapeutic Committee are a must.

2.
Indian J Med Sci ; 2006 Apr; 60(4): 143-53
Artigo em Inglês | IMSEAR | ID: sea-67895

RESUMO

BACKGROUND: Carnitine insufficiency is responsible for various co-morbid conditions in maintenance hemodialysis (MHD) patients. L-carnitine supplementation is expected to improve the quality of life (QoL) of patients on MHD. AIMS: To study the effect of L-carnitine supplementation on QoL of Indian patients on MHD. SETTING AND DESIGN: This was a single (patient) blind, randomized, placebo-controlled clinical trial conducted on patients on MHD attending hemodialysis unit of the study center. MATERIALS AND METHODS: Twenty patients on MHD suffering from hemodialysis-related symptoms were randomly assigned to receive intravenous L-carnitine 20 mg/kg or placebo after every dialysis session for 8 weeks. SF36 (Short Form with 36 questions) score for QoL, laboratory investigations and dialysis related symptoms were recorded at baseline and after 8 weeks. Improvement in QoL, laboratory parameters and dialysis related symptoms in the two groups after 8 weeks was compared. STATISTICAL ANALYSIS USED: Depending on normality of data, unpaired T test or Mann Whitney U test was used for comparison of change (8 weeks-baseline) in SF36 scores and laboratory parameters observed in the two groups. RESULTS: L-carnitine supplementation increased total SF36 score by 18.29 +/- 12.71 (95% CI: 10.41 to 26) while placebo resulted in reduction in total SF36 score by 6.4 +/- 16.39 (95% CI: -16.59 to 3.73). L-carnitine also resulted in significant increase in hemoglobin and serum albumin and decrease in serum creatinine as compared to placebo. More patients were relieved of dialysis related symptoms in L-carnitine group. CONCLUSION: Intravenous L-carnitine supplementation improves QoL in patients on MHD.


Assuntos
Adulto , Carnitina/administração & dosagem , Suplementos Nutricionais , Feminino , Humanos , Índia , Injeções Intravenosas , Falência Renal Crônica/sangue , Masculino , Pessoa de Meia-Idade , Cãibra Muscular/prevenção & controle , Debilidade Muscular/prevenção & controle , Qualidade de Vida , Diálise Renal/efeitos adversos , Método Simples-Cego
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