Determinants of oxidative stress and DNA damage (8-OhdG) in squamous cell carcinoma of head and neck.

Background: Squamous cell carcinoma of head and neck (SCCHN) is a major concern of health risk in developing countries, such as India. Apart from genetic configuration, environmental and lifestyle factors, as well as poor oral hygiene, provide free radical-generating environment, which may contribute to the development of cancer through DNA damage. Materials and Methods: Here we ascertained the various oxidative stress determinants in diagnosed SCCHN patients with health risk addictions. This study further evaluated the incremental effects inflicted by these lifestyle factors on redox status. The study included 100 consenting SCCHN patients and 90 matched healthy controls. Salivary total antioxidant capacity (TAC), glutathione (GSH), free radicals: such as reactive nitrogen species (RNS) and reactive oxygen species (ROS) along with oxidative DNA adduct (8-OHdG) were monitored. Results: Our findings indicated altered salivary oxidant-antioxidant status in SCCHN. A substantial rise in ROS (~2.0 folds) and RNS (~1.4 folds), together with significant lowering in TAC (~1.2 folds) and GSH (~1.7 folds) was observed. The 8-OHdG levels were also found to be considerably higher (P < 0.001) in salivary cell's DNA of these patients. Conclusions: Our results demonstrate significant redox imbalance in cancer patients suggesting their paramount importance in the development of SCCHN.

A study of Late Onset Schizophrenia Clinical Characteristics with Review of Literature.

That schizophrenia does manifest for the first time in old age, has been recognized for a long time. A number of recent epidemiological studies have also documented its onset in old age. It has remained controversial, however, if schizophrenia occurring for the first time in old age is different substantially from schizophrenia manifesting at younger age. A number of efforts have been going on in recent years in different parts of the world to document differences and similarity between two groups on parameters like clinical features, family history, psychopathology, treatment response, and prognosis and outcome. Many studies have appeared on neuroimaging and neurobiology of late onset schizophrenia. Some efforts have also been done in India on this entity. The present study is to examine clinical characteristics of late onset schizophrenia on number of standardized structured instruments. The study compares its results with some well known studies.

Modulation of acute cadmium toxicity by Emblica officinalis fruit in rat.

The efficacy of Emblica officinalis in modifying the acute cytotoxicity of cadmium in male rats was evaluated. Oral administration of Emblica fruit juice (500 mg/kg, b.w.) for 8 days followed by a single toxic dose of Cd as CdCl2 (3 mg/kg,b.w. ip), considerably reduced the mortality in rats as well as prevented to some extent the cadmium induced histopathological damage in testis, liver and kidneys. Biochemical investigation also revealed reduced levels of Cd induced serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and gamma glutamyltranspeptidase. The enhanced levels of Cd and lipid peroxidation in liver, kidney, and testes and metallothionein and total sulphydryl in liver and kidney by Cd were significantly reduced by Emblica pretreatment. These results suggest cytoprotective potential of Emblica fruit in acute cadmium toxicity which could be due to its multiple role in biological system.

Depressive disorders in old age.

People are living longer life since with the improvement in health and medical services provided. Developing countries are not lagging behind the developed world as far as the life expectancy is concerned. The principal mental disorders of elderly people are mood disorders and dementia. In older people living in a community the rates of depressive disorders are likely to be the same as for all age groups of the general population, yet its prevalence in old age institution is high. Aetiology of depression in old age is caused by a variety of conditions namely genetic factors, physiological changes in all the systems, disability, loss of resources, some medical illness, etc. Clinical features include depressed mood most of the day, significant weight loss, persistent sleeplessness, fatigue, feelings of worthlessness, recurrent thoughts of death and suicidal attempt, etc. Tricyclic antidepressants are effective in elderly depressives. Selective serotonin re-uptake inhibitors are well tolerated by elderly patients and are effective too. Electroconvulsive therapy is an alternative treatment of acute depression. Psychotherapy is often helpful and long-term care should be planned for to reduce disability.