Synthesis, in silico study and in vitro anti-microbial evaluation of some new N-benzoyl-N'-[2-(4-chloro-phenoxy)-acetyl]-hydrazides analogs

In bacterial resistance duty, the prompt increase against existent anti-microbial drugs is a challenging universal healthproblem. Bacteria represent a highly significant threat globally to healthcare-associated infections, also responsiblefor the majority of hospital infections, which leads to an increase in the mortality and burden of worldwide healthcareduty. In this investigation, we reported the synthesis novel substitutes of phenoxy hydrazide analogs (6a–f) andhave been screened for in vitro anti-bacterial and anti-fungal activities to determine the inhibition zone by using thepaper disk agar diffusion technique and broth dilution to evaluate the minimum inhibitory concentration values. Thestructure–activity relationship suggest that among the series (6a–f), compounds (6e) with two chloro groups and (6f)with four fluoro groups showed good inhibition against pathogenic microbes. Furthermore, these results were alsoconfirmed by the in silico study. Based on this studies, there are a scopes of developing compounds (6e) and (6f) intopotent anti-microbial drugs in the near future.

Efficacy of 5-(2-aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles as antibacterial and antifungal agents.

Research and development of potent and effective antimicrobial agents represent one of the most important advances in therapeutics; the main aim of these efforts is not only control the serious infections, but also prevention and treatment of some infectious complications of other therapeutic modalities. A series of 5-(2- aroyl)aryloxy methyl-2-phenyl-1,3,4-oxadiazoles were screened for their antibacterial and antifungal activities. Anti-bacterial activity against B. cereus, S. aureus, B. subtilis, S. aureus (MRSA), E. aerogenes, M. luteus, K. pneumonia, P. aeruginosa, S. typhimurium, E. coli, paratyphi-B, P. vulgaris bacterial strains and anti-fungal activity against C. albicans, A.niger, F.solani, A.flavus, B.cinerea, C.krusei, M. pachydermatis, C.parapsilosis, F.moniliforme, C.gloeosporioides fungal strains were carried out. The bioassays indicated that most of the synthesized compounds showed potential antibacterial and anti-fungal activity.