RESUMO
In the present work, we have designed short chain α-helical linear and cyclic peptide from cecropin B having samecharge, hydrophobicity, and helicity. The designed compounds were synthesized by using solution phase method.Elucidation of structure of newly synthesized peptides was done by proton nuclear magnetic resonance, Carbon-13nuclear magnetic resonance, Fourier-transform infrared spectroscopy, Fast atom bombardment mass spectrometry,and elemental analysis. Furthermore, the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltratrazolium bromide assay wasperformed for cytotoxicity of synthesized compounds against Dalton’s lymphoma ascites (DLA), Ehrlich’s ascitescarcinoma (EAC), and Michigan Cancer Foundation-7 cell lines using 5-FU as a reference compound. Biologicalevaluation showed that short chain cyclicpeptides were more potent than linear peptides against EAC and DLA celllines.