Expression of cyclooxygenase-1 in epithelial ovarian cancer: a clinicopathological study.

OBJECTIVE: To determine immunohistochemical expression of cyclooxygenase-1 (COX-1) in epithelial ovarian cancer (EOC), and its association with clinical features and prognosis. METHODS: EOC patients treated in Bangkok Metropolitan Administration Medical College and Vajira Hospital during 1996-2003, and with available pathological tissue sections, were identified. Immunohistochemical staining was accomplished with antibodies to COX-1 and degree of expression was categorized into low and high for assessment of any. association with clinicopathological factors and survival. RESULTS: One-hundred and seven patients were included in the study, with a median age of 50 years. Most had stage I and III disease. The most common histologic subtype was serous carcinoma. Overall, we found COX-1 expression in 83.2 %. Non-mucinous lesions had significant higher levels of expression than mucinous tumors, but there was no link expression with other clinicopathological factors or survival. CONCLUSIONS: EOCs showed highexpression of COX-1, especially with a non-mucinous histology, but this appears to lack prognostic significance.

Prevalence of high grade squamous intraepithelial lesions (HSIL) and invasive cervical cancer in patients with atypical squamous cells of undetermined significance (ASCUS) from cervical pap smears.

To determine the prevalence and factors associated with histologic diagnoses of High Grade Squamous Intraepithelial Lesions (HSIL) or invasive cervical cancer in women with a cytologic diagnosis of atypical squamous cells of undertermined significance (ASCUS), medical records of women with an ASCUS Pap smear from January 2003 to December 2006 were reviewed. Of 287 women with ASCUS Pap smears in whom data were available, 189 were annotated with "favoring a premalignant or malignant process", 74 with "favoring reactive", and 24 with "not otherwise specified". The prevalences of HSIL and invasive cervical cancer were 9.1% and 1.2%, respectively. Only subtypes of ASCUS were significantly associated with the detection of HSIL or invasive cancer, 12.7% with favoring premalignant or malignant process, 2.7% with favoring reactive, and 16.7% in with ASCUS-NOS (p=0.034).

Prevalence of high grade squamous intraepithelial lesion (HSIL) and invasive cervical cancer in patients with low grade squamous intraepithelial lesion (LSIL) at cervical pap smear.

OBJECTIVE: To assess the prevalence and factors associated with a histologic diagnosis of high grade squamous intraepithelial lesion (HSIL) and invasive cervical cancer in patients with low grade squamous intraepithelial lesion (LSIL) cervical pap smear findings. METHODS: Medical records (including cytology reports, colposcopic impression, and pathologic results from cervical biopsy, endocervical curetting, cervical conization or hysterectomy) of 226 women with LSIL from conventional cervical pap smears during January 2001 to December 2005, who subsequently underwent colposcopic evaluation at our institution, were reviewed. RESULTS: Mean age of the patients was 39.0 years. The incidences of LSIL, HSIL, microinvasive cervical cancer were 58.8%, 15.0%, 1.3% respectively. No associations were found between age, parity, contraception, anti-HIV or menstrual status and the detection of HSIL/invasive cervical cancer. CONCLUSION: Approximately 16.3 % of LSIL pap smear cases turn out to be HSIL or invasive cervical cancer from histologic diagnosis.