RESUMO
Background: Diabetic nephropathy (DN) is the foremost cause of morbidity and has become the mostrecurrent cause of end-stage renal disease among diabetic patients. Thus, agents having antidiabeticeffect along with safety potential in the kidneys would have a higher remedial value.Objective: The present study aimed to investigate possible protective effect of homeopathic preparationof Cephalandra indica Mother tincture, 6C and 30 C potencies on DN in Wistar rats.Materials and methods: DN was induced by intraperitoneal injection of STZ (60 mg/kg) 15 min afterNicotinamide (230 mg/kg, i.p.) administration. Rats were divided into six groups (n ¼ 6). Group 1 and 2was kept normal control and diabetic control respectively whereas Groups 3e5 consist of diabetic nephropathy rats treated with different doses of C. indica Mother tincture, 6C and 30 C potencies for 45days. Glimepride (10 mg/kg) was used as standard. DN was assessed by determining serum glucose, urea,uric acid, creatinine level and tissue histological examination. Tissue antioxidant enzymes (SOD, GSH,LPO) level was measured to assess the oxidative stress. Also, the level of advanced glycation end productsin kidney was determined.Results: Mother tincture, 6C and 30 C potencies of C. indica produced significant attenuation in thebiochemical parameters used to assess diabetic nephropathy. Moreover, oxidative stress and AGE's levelin kidney was also found to be significantly reduced.Conclusion: We conclude that Mother tincture, 6C and 30 C potencies of C. indica confers protective effectagainst diabetic nephropathy via inhibition of Oxidative stress and AGE's.© 2017 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Publishing Services byElsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).