In vitro antileishmanial activities of some imino compounds

Nineteen imino compounds were tested against the in vitro growth of Leishmania major. A high percentage of growth inhibition [range 79-87%] was observed with imines containing the derivatives phthalimide, thiazole-sulphonamide and isoxazole. The I [50] was the lowest [3 micro g/ml] for imino inhibitors containing the combined thiazole-sulphonamide derivatives, indicating a higher potency of parasite inhibition than the rest of imines tested