RESUMO
INTRODUCTION: Maximum open surgeries are being replaced with laparoscopic surgeries. Laparoscopic cholecystectomy is being more commonly prac?ced than open surgery. Many parenteral or oral medica?ons are used to control post opera?ve pain following laparoscopic cholecystectomy do have their own side effects. So, local ins?lla?on will be beneficial with lesser or negligible side effects. The present study was conducted to compare the effect of intraperitoneal ins?lla?on of 0.25% Bupivacaine with Dexmedetomidine and 0.25% Bupivacaine with Fentanyl to know which combina?on has be?er efficacy in pa?ents of Laparoscopic Cholecystectomy. METHODOLOGY: The present compara?ve study was carried on pa?ents posted for Laparoscopic Cholecystectomy in a ter?ary care hospital during 2019 to 2022, The pa?ents were divided in two equal groups of 40 each with Group D - Pa?ents receiving 0.25% bupivacaine with Dexmedetomidine and were ins?lled with 30ml of 0.25% bupivacaine with 1 µg/kg Dexmedetomidine (diluted in 2 ml Normal Saline). Also, Group F - Pa?ents receiving 0.25% bupivacaine with Fentanyl where pa?ents were ins?lled with 30ml of 0.25% bupivacaine with 1 µg/kg Fentanyl (diluted with 2 ml Normal saline NS). Degree of postopera?ve pain was assessed using Visual Analogue Scale (VAS). RESULTS: Overall VAS in 24 hrs was significantly lower in the D group compared to F group. The ?me required for the first dose of rescue analgesia was longer in the D group than in F group, indica?ng be?er and longer pain relief in the D group compared to that of F group. The difference was also sta?s?cally significant among the two groups. Total analgesic consump?on was high in F group than in the D group. CONCLUSION: We concluded that intraperitoneal ins?lla?on of dexmedetomidine 1 µg/kg in combina?on with 0.25% Bupivacaine in elec?ve laparoscopic cholecystectomy significantly reduces the post opera?ve pain and analgesic requirement in postopera?ve period.