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Migraine is a complex neurological condition, which can affect the whole body and can result in many symptoms as nausea, vomiting, photophobia (Increased sensitivity to light), phonobhobia (Increased sensitivity to sound) and osmophobia (Increased sensitivity to smell). Neurological symptoms that include visual disturbances such as blind spots, distorted vision, flashing lights or zigzag patterns. Other common symptoms includes- dizziness, vertigo, tingling sensations in the limbs, an inability to concentrate, confusion, difficulty in speaking, paralysis or loss of consciousness (in very rare cases). These symptoms, often called ‘aura’. Migraine attacks may differ in their frequency, duration and severity, although, normally they last between 4 and 72 hours, and most people are symptom-free between attacks. There are many drugs for the treatment of acute attack of migraine which can be divided into mild, moderate and severe attacks. In mild case NSAIDs like Paracetamol, Ibuprofen are prescribed. In moderate cases Anti-emetics like metoclopramide, domperidone can be prescribe with combinations of NSAIDs or triptans as sumatriptan. In case of severe cases triptans can be prescribed with ergot alkaloids and antiemetics. Following drugs are prescribed for the prophylaxis of migraine as sodium valproate, amitriptyline (Tricyclic antidepressant), propranolol and metoprolol (beta blockers). Erenumab-aooe is a calcitonin gene-related peptide receptor antagonist. It is specifically indicated for the preventative treatment of migraine in adults. Erenumab-aooe is supplied as an injection for subcutaneous use. The recommended dosage is 70 mg injected subcutaneously once monthly. Some patients may benefit from a dosage of 140 mg injected subcutaneously once monthly, which is administered as two consecutive subcutaneous injections of 70 mg each. Erenumab-aooe is a human monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor and antagonizes CGRP receptor function.
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Background: Free health camp is a common objective of non-governmental organization (NGO). Government health department alone or jointly with NGO use to organize free medical camp for some specific health program. This retrospective study of occurrence and proportion of diseases and their pattern of treatment was done for period from 2005 to 2017 with an NGO has been working in East Singhbhum district of Jharkhand.Methods: The data of patients over the age of 05 years attended the free health camp from 2005 to 2017 and consent were provided by NGO concerned in this study. The year wise, block wise number of patient, male/female ratio and list of drugs used in different time were tabulated for analysis.Results: The result of this study has been noted in four different tables which elaborates the total number of patients year wise, block wise, percentage wise, male/female ratio during thirteen years. Another table showed occurrence of diseases/ailments in different period with changing percentage of use the drugs in their treatment.Conclusions: This retrospective study provides a conception about some changes in occurrence of diseases in free medical camp in the rural areas of Jharkhand in thirteen years. These health camps have tried to provide and follow the treatment according to need of the patients with safer, efficacious, economical drugs and with periodical inclusion of new generation drugs.
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Background: Overweight and obesity are chronic medical condition responsible for risk factors for many non-communicable diseases. Development of rapid upsurge of these condition in medium and low-income group countries increased the awareness and uses of many types of remedies. Along with other natural herbal products green tea and green coffee have also became popular in communities. Aim of this study was to compare the effect of green tea and green coffee on blood cholesterol and weight in experimental animals.Methods: The experiment of this study was conducted in the Department of Pharmacology, MGM Medical college, Jamshedpur after ethical approval. 24 albino rats were selected and divided randomly in four groups A B C D. Group ‘A’ was kept as control group, group ‘B’ was given fat rich diet to produce hypercholesterolemia, group ‘C’ and ‘D’ were given green tea and green coffee respectively along with cholesterol rich diet. Weight and cholesterol level of rats were measured on 1st day, 2nd week and 4th week.Results: There was significant increase in serum cholesterol in non-treated animals as compared to control group but parameter showed significant less rise of cholesterol and weight in treated group by both green tea and green coffee than non-treated group. The comparative effect of green tea and green coffee had not much difference.Conclusions: This study has provided the information that natural products like green tea and green coffee are useful and helpful in preventive therapy of dyslipidemia and obesity.
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A pot experiment was conducted at six graded levels of copper (Cu) viz., 0, 0.5, 1.0, 1.5, 2.0 and 2.5 mg kg-1 to test the response of wheat plants grown in a copper-responsive alluvial soil (entisol) under glass house conditions. The growth attributes like plant height, fresh and dry matter yield, percent dry matter enhanced with increasing Cu levels and was maximum at 1.5 mg kg-1 Cu while the number of tillers was minimum at this level. The grain yield at 1.5 mg kg-1 Cu was enhanced by 62.9% from the control. The increase in weight of 1000 grains ranged from 33.93 to 41.35 g in comparison to control (32.58 g). Harvest index (%) also increased and ranged from 39.42 to 47.73 in different treatments in comparison to control (35.92). Both 1000 grain weight and harvest index were maximum in the plants at 1.5 mg kg-1 copper. Cu concentrations in leaves, grain and straw enhanced with increasing levels of Cu application. The Fe concentration in leaves was significantly reduced by Cu application and the reduction was 10.3% at 2.5 mg kg-1 Cu and was not influenced in by Cu application in grain and straw. The Mn concentration was not affected by Cu application in any of the plant part studied. However, Zn concentration decreased significantly at higher levels of Cu (2.0 and 2.5 mg kg-1) in leaves and remained unaffected in the grain and straw.
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The pattern of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in the Indian population is poorly known. In order to determine the status of the polymorphism, young unrelated male army recruits were screened. The population had cultural and linguistic differences and lived in an environment that varied significantly from one region to another. Analysis of the genotype, showed higher frequency of the insertion allele in four of the five groups i.e. I allele frequency was significantly higher (P < 0.05) in Dogras, Assamese and Kumaonese. The deletion allele frequency was comparatively higher in the fifth group that belonged to Punjab. A correlation was observed between the genotype and enzyme activity. Involvement of a single D allele in the genotype enhanced the activity up to 37.56 3.13%. The results suggested ethnic heterogeneity with a significant gene cline with higher insertion allele frequency. Such population-based data on various polymorphisms can ultimately be exploited in pharmacogenomics.