An Interventional Study of Physical Activity on HbA1C and VO2max in Type 2 Diabetes Mellitus.

Low cardio-respiratory fitness is prevalent in type 2 diabetics. The objectives of the present study was to assess the effect of an exercise on VO2max and HbA1c in type 2 diabetic patient. The baseline VO2max and HbA1c of 30 diabetics were estimated. VO2max was estimated using the Bruce protocol. HbA1c was measured by ion-exchange chromatography with Bio-Rad D10. After an exercise regimen for a period of 6 months, they returned to check their VO2max and HbA1c. The baseline VO2max was 32.67±11.99 ml/kg/min (low for given age) and HbA1C% values were high (7.58±1.66). After walking it was found that VO2max increased and HbA1c decreased significantly. Exercise improves cardiorespiratory fitness and lower HbA1c. So, a suitable exercise should be incorporated along with diet and drug prescription.

Scimitar syndrome: a rare congenital venolobar anamoly.

Scimitar syndrome is a rare congenital anomaly presenting with partial anomalous pulmonary venous drainage from right lung to inferior vena cava. This is the rarest anomaly seen in 1 to 3 in 100000 births. Embryologically it is thought to be a primary developmental anomaly of lung with secondary anomalous venous drainage. This is seen commonly in right lung and is common in females. Most of the cases are asymptomatic or minimally symptomatised. If symptoms are present patient usually presents with pulmonary hypertension and symptoms of left to right shunt. Clinically this syndrome is diagnosed by chest x- ray by the presence of “Scimitar sign”. Surgical treatment effective in this syndrome.

Giant intermuscular lipoma of neck and chest: a case report with review of literature.

Intermuscular lipoma is an uncommon benign tumor. In this case report we described a case of a patient with intermuscular lipoma located between sternocleidomastoid, pectoralis and scalene muscles on left side. These typ es of tumors are exceedingly rare in head and neck regions. Intermuscular lipomas are thought to arise from the Intermuscular septa and enlarge between muscle bundles. Clinical data, investigations, Magnetic Resonance Imaging scan confirm the diagnosis. These tumours are more common in males than females. Complete surgical excision of tumor is the treatment of choice. It is crucial for the surgeon to consider deep lipomas when dealing with soft tissue tumors.

Schwannoma arising from hypoglossal nerve in the submandibular triangle: a case report.

Hypoglossal schwannomas usually develop in the intracranial portion of the brain. The incidence of hypoglossal schwannomas of the submandibular region is extremely rare. Here we report a case of schwannoma arising from the extracranial hypoglossal nerve in the left submandibular region.

Mixed germ cell tumour of testis: a case report with review of literature.

Testicular tumours are rare neoplasm. Mixed germ cell tumour is the most common histological variant. Essentially, any admixture of the germ cell tumours as seen in pure form may be seen, one of the most common admixtures being embryonal carcinoma and teratoma. Unfortunately many of these patients present late usually with some complications. We present a rare case of mixed germ cell tumour with predominant embryonal carcinoma and yolk sac tumour in adolescent patient with multiple metastatic foci at the time of presentation.

Idiopathic gynaecomastia in twins: a case report.

Gynaecomastia is a common pathological condition of breast seen in men. This is defined as benign enlargement of breast tissue in males. It was first described by Palus Aegineta (AD 635-690). Herewith we are presenting cases of 14 year old twins attending the surgical O.P.D with bilateral enlarged breasts and pain. A diagnosis of pubertal gynaecomastia was made with no evidence of malignancy by histopathological examinations and mammography. One boy with 5 x 6 cm of right breast and 2 x3 cm of left breast was treated by subcutaneous mastectomy. Other boy had only enlargement of nipple and areola. He was reassured and sent home without surgical intervention. A rare case of idiopathic gynaecomastia in pubertal twins is described here.

Malignant melanoma of breast: a case report.

Malignant melanoma rarely affects the breast. Malignant melanoma of breast is divided into two categories: primary and metastatic lesions. Primary melanoma involves the skin and less commonly the glandular parenchyma of the breast. Differentiating them is very important in deciding on treatment strategies. This case report aims to increase awareness of unusual neoplasms of the breast which requires a different surgical and adjuvant therapeutic approach.

Hepatoprotective effect of Pergularia daemia (Forsk.) ethanol extract and its fraction.

Ethanol extract and its ethanol fraction from aerial parts of P. daemia exhibited significant hepatoprotective effect against CCl4 induced hepatotoxicity in rats. Glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, total bilirubin, total cholesterol, total protein and albumin in serum indicated hepatoprotective effect of the ethanol extract and its ethanol fraction. Histopathological examination of liver sections confirmed that, pre-treatment with ethanol extract and its ethanol fraction prevented hepatic damage induced by CCl4. The results were comparable with the standard hepatoprotective drug silymarin. The extract and its fraction showed no signs of toxicity up to a dose level of 2000 mg/kg. It is suggested that, the presence of flavonoids in ethanol extract and its ethanol fraction may be responsible for hepatoprotective properties. High Performance Thin Layer Chromatography profile of flavonoids of bio-active extracts was developed using quercetin-3-glucoside as a marker. Results indicate hepatoprotective properties of ethanol extract of P. daemia.

Pattern of opportunistic pulmonary infections in HIV sero-positive subjects: observations from Pondicherry, India.

Prospective analysis for a period of six-and-a-half years was done in 190 patients with HIV infection, which showed post-primary tuberculosis with sputum positive for acid-fast bacilli in 65% of cases. Extrapulmonary forms of tuberculosis especially lymph nodes infection was more frequent. Cervical group of lymph node involvement was the commonest presentation. Procedures such as FNAC/biopsy of lymph nodes and pleura provided the immediate diagnostic yields. These procedures must be considered early in the course of illness of HIV infected patients with suspected extrapulmonary and disseminated tuberculosis. Tuberculosis constitutes a common pathology with an appreciable mortality in disseminated subjects. Majority of patients with tuberculosis responded to 2EHRZ/7HR therapy indicating infection by Mycobacterium tuberculosis rather than by atypical mycobacteria, without any serious adverse reactions. Retrospective analysis of two groups (February 1991-May 1994) and (June 1994-October 1997) shows a significant increase in disseminated tuberculosis and Pneumocystis carini pneumonia indicating late stage of HIV disease.