RESUMO
Regional anaesthesia is a commonly used technique in orthopedic procedures. Sedation during regional anaesthesia reduces patients anxiety, increases patient comfort with improvement in operating conditions during surgery. The present study compared the cardiopulmonary parameters amongst subjects during regional anaesthesia with propofol sedation with or without midazolam premedication and effect of midazolam premedication on propofol requirement. Methods: A total of forty, ASA grade I- III patients aged 25 to 65 years who were scheduled for total hip or knee replacement surgery under combined spinal epidural were included in this study. Patients in group I (n= 20) were started on propofol infusion alone for sedation after giving regional anaesthesia and group II (n=20) patients were given Inj Midazolam 2 mg im 30 min before arrival in OT given regional anesthesia and then started on propofol infusion. This was followed by monitoring of blood pressure, pulse rate and oxygen saturation. All the data thus obtained was arranged in a tabulated form and analysed using SPSS software. Mean of all values was recorded. Results: In group I, the pulse rate preoperatively was 83.4±10.6 and in Group II it was 79.1±11.1. At 15 mins, the pulse rate in Group I and Group II was 64.4±10.0 and 85.9±12.9 respectively. In group I, the oxygen saturation preoperatively was 98.6±0.66 and in Group II it was 98.8±0.65. At 15 mins, the oxygen saturation in Group I and Group II was 99.7±0.45 and 99.6±0.47 respectively. At 60 mins, the blood pressure in Group I and Group II was 96.4±5.9 and 94.2±3.8 respectively. Conclusion: There was no significant difference in the hemodynamic parameters amongst both the groups. Therefore, midazolam can be safely used with propofol. The dose of propofol needed for sedation is also reduced.