RESUMO
Asrigdar has been characterised by excessive bleeding per vaginum. Acharya Charaka described Asrigdar as a separate disease along with its treatment in Yoni Vyapada Chikitsha Adhyaya. Acharya Charaka also described it as a Raktaja Vikara. Acharya Sushruta described Asrigdar due to Pitta Samyukt Apana Vayu. It can be correlated with Abnormal Uterine bleeding in modern. Any uterine bleeding other than normal duration, frequency and volume is considered as abnormal uterine bleeding. It affects about 30% of women in reproductive period. It is often associated with backache, pain in lower abdomen and weakness. A 23 years old female patient presented with complaints of Irregular menses with excessive bleeding per vaginum associated with pain lower abdomen. On further enquiry it was found that she had irregular menses since menarche. She took modern treatment but didn’t get significant relief. Due to excessive bleeding she had Anaemia also. Keeping all the aspects in mind a treatment has been planned. Doshas involved in Asrigdar are mainly Pitta and Vata, That is why, for Samprapti vighatan basic treatment divided into three parts i.e. Shaman chikitsha along with Sthanik chkitsha over abdomen with Krishna Mritika and Basti chikitsha. Shaman chikitsha which includes Pitta and Vata shamak, Raktastambhaka and Balya Aushadh. In Bhavprakash Nighantu Krishna Mritika has been kept in Ashtama Dhatwadi Varga and mentioned in Rakta Pradra or Rakt Vikara. The treatment protocol was followed for three cycles with positive outcome as better cycle control and symptomatic improvement in this patient.
RESUMO
TB remains a leading cause of morbidity and mortality in developing countries. The incidence of congenital TB is underestimated. Current recommendations regarding the management of neonates of mothers with tuberculosis are variable and no tangible guidelines have been advised. Congenital TB is fatal if untreated, moreover the mortality and morbidity is increased if the diagnosis and treatment is delayed. Therefore, the treating clinician should be aware of the unusual presentation of congenital TB. A high suspicion and good screening of mothers and neonates is of paramount importance. Congenital tuberculosis is diagnosed by Cantwell criteria. Isoniazid prophylaxis for 6 months is recommended in neonates born to mothers with TB who are infectious. Breastfeeding should be continued, and isolation is recommended only in certain circumstances such as mother is infectious, has multidrug resistant tuberculosis or non-adherent to treatment. BCG vaccine is recommended in all neonates however, the timing of administration varies according to various guidelines. Neonate diagnosed with congenital TB should be treated with anti-tubercular drug regimen.
RESUMO
Background & objectives: Phlebotomus argentipes (Diptera: Psychodidae), the established vector for kala-azar is presently being controlled by indoor residual spray of DDT in kala-azar endemic areas in India. Search for non-hazardous and non-toxic biodegradable active molecules from botanicals may provide cost-effective and eco-friendly alternatives to synthetic insecticides. The present study was aimed at evaluating various plant extracts from endemic and non-endemic areas of Bihar for their insecticidal activity against sandfly to identify the most effective plant extract. Methods: Bio-assay test was conducted with larvae and adult of P. argentipes with different plant extracts collected in distilled water, hexane, ethyl acetate, acetone and methanol. Thin layer chromatography (TLC), column chromatography and high performance liquid chromatography (HPLC) were conducted for detection of active molecules. Results: Adults and larvae of sandflies exposed to the aqueous extract of Nicotiana tabacum resulted in 100 per cent mortality. The hexane extract of Clerodendrum infortunatum was found to kill 77 per cent adults but was ineffective against larvae. Bio-assay test of the ninth fraction (hexane extract-methanol phase) separated by column chromatography was found to be 63 per cent effective. The purple spot on the TLC of this fraction indicated the presence of a diterpenoid. HPLC of this fraction detected nine compounds with two peaks covering 20.44 and 56.52 per cent areas with retention time of 2.439 and 5.182 min, respectively supporting the TLC results. Interpretation & conclusions: The column separated 9th fraction of C. infortunatum extract was found to be effective in killing 63 per cent of adult P. argentipes. Compounds of this fraction need to be evaluated further for identification and characterization of the active molecule by conducting individual bio-assay tests followed by further fractionation and HPLC. Once the structure of the active molecule is identified and validated, it may be synthesized and formulated as a product.