A Study On The Dietary Habits And Their Association With The Symptoms In Patients With Hemorrhoids And Fissure-in-Ano: A Case Control Study From A South Indian Tertiary Care Hospital

DOI: 10.21276/aimdr.2018.4.2.SG4 Original Article ISSN (O):2395-2822; ISSN (P):2395-2814Annals of International Medical and Dental Research, Vol (4), Issue (2) Page 11Section: Surgery A Study On The Dietary Habits And Their AssociationWith The Symptoms In Patients With Hemorrhoids And Fissure-in-Ano: A Case Control Study From A South Indian Tertiary Care Hospital. Shaffaf M P1, Kunhi Mohammed K P2, Siddharth Matad3 1Junior Resident, Department Of Surgery, Government Medical College, Manjeri, Kerala, India. 2Assistant Professor, Department Of Surgery, Government Medical College, Manjeri, Kerala, India. 3Senior Resident Department Of Surgery, Government Medical College, Kozhikode, Kerala, India. Received: January 2018 Accepted: January 2018 Copyright:© the author(s), publisher. Annals of International Medical and Dental Research (AIMDR) is an Official Publication of “Society for Health Care & Research Development”. It is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.ABSTRACT Background: Both hemorrhoids and fissure-in-ano contribute to the spectrum of anorectal disorders which generate significant patient discomfort and disability. Etiological factors associated with development of symptomatic hemorrhoids include intake of low fiber diet, inadequate fluid intake, altered bowel habits leading to constipation etc. Aim: 1.To study the dietary habits of patients presenting with haemorrhoids and fissure in ano. 2. To determine the effect of altered dietary habits on the symptomatology. Methods: Case Control study conducted over one year between august 2016 to august 2017 at Department of surgery, Government Medical College, MANJERI. Results: The mean age of patients having hemorrhoids is 42.9years in case group and 44.0years in control group. Where as, the mean age of patients with fissure-in-ano is 37.1years in case group and 39.6years in control group. Majority of patients in the study population of hemorrhoids are male (84%) while female patients (56%) have more anal fissures. The p value of all analysis is <0.05. Conclusion: From this study, it has been concluded that in patients with hemorrhoids, bleeding per rectum gets aggravated with consumption of non vegetarian food items, fasting in the morning and intake of ≤ 1L of oral liquids and reduced consumption of diet containing fibre.

Defective repair of UV-induced DNA damage in cultured primary skin fibroblasts from Saudi thyroid cancer patients.

This study was conducted to examine the sensitivity of primary skin fibroblasts from Saudi thyroid cancer (TC) patients to ultraviolet (UV) irradiation. Cell survival was studied by a colony forming assay and DNA repair defects with a host cell reactivation (HCR) assay using UV-irradiated Herpes Simplex Virus (HSV). In addition, p53 gene expression was examined in the same TC cells exhibiting enhanced radiosensitivity. Skin fibroblasts from TC patients (n=4) showed significantly enhanced sensitivity to UV radiation. The average UV dose to reduce survival to 37% of the initial survival (D(37)) value (in Jm(-2)) for fibroblasts from TC patients was 4.6 (3.7-5.6) compared to 7.3 (6.3-8.3) for healthy individuals (n=3). UV-sensitive xeroderma pigmentosum (XP) cells, which were used as positive control, were found to be extremely sensitive with a D(37) value of 0.6 Jm(-2). In a host cell reactivation assay, UV-irradiated HSV was tested for its plaque-forming ability (PFA), by plating infected fibroblasts from TC patients (used as host cells) on African Green Monkey (Vero) kidney cells to form plaques. A significant reduction in the PFA of the UV-irradiated virus (about three fold) on TC cells compared to fibroblasts from the healthy subjects was seen, suggesting a DNA-repair deficiency in the primary fibroblasts of the TC patients. Furthermore, no significant accumulation in radiation-induced p53 expression was observed in cells from the TC patients. Our results, based on a relatively small group of subjects, indicate that Saudi TC patients primary fibroblasts (non-cancerous in nature) may be carriers of cancer-susceptible gene(s) arising from defective DNA repair/processing. These results warrant a larger study to investigate the role of UV-induced bulky DNA damage in thyroid cancer susceptibility.