Effects of Mirodenafil, a Phosphodiesterase-5 Inhibitor, on Female Rat Bladder in a Partial Bladder Outlet Obstruction Model: Physiological and Immunohistochemical Aspects

PURPOSE: We investigated the effects of mirodenafil, a phosphodiesterase-5 inhibitor developed in South Korea, on the female rat bladder in a partial bladder outlet obstruction (BOO) model. MATERIALS AND METHODS: Thirty-six female Sprague-Dawley rats were divided into four groups: the control group, BOO without medication group, BOO with mirodenafil 1 mg/kg group, and BOO with mirodenafil 4 mg/kg group. Mirodenafil was administered orally for 2 weeks after the induction of BOO. Two weeks after BOO, the rats in each group underwent cystometry under urethane anesthesia. After cystometry, the bladder was excised to perform immunohistochemical staining for connexin 43. RESULTS: The three BOO groups showed significant increases in mean bladder weight compared with the control group. Baseline pressure, threshold pressure, and maximum contraction pressure were not significantly different between the four groups. Although the contraction interval was decreased in all BOO groups compared with the control group, it was prolonged in the two groups treated with mirodenafil compared with the untreated BOO group. In the immunohistochemical examination, connexin 43 staining intensity in the lamina propria increased in the three BOO groups compared with the control group. The two groups treated with mirodenafil, however, showed decreased connexin 43 staining compared with the untreated BOO group. CONCLUSIONS: Mirodenafil may increase the contraction intervals of female rat bladders in a partial BOO model. Decreasing bladder overactivity by mirodenafil may be related to intracellular communication mechanisms involving connexin 43.

Analysis of Octyl-2-Cyanoacrylate as a Dressing Material after Pediatric Urological Procedures

PURPOSE: We aimed to evaluate the efficacy of Octyl-2-cyanoacrylate (Dermabond(TM)) as a topical skin adhesive for pediatric urologic open surgery. METHODS: From August 2010 to August 2011, we retrospectively evaluated pediatric patients who underwent urologic open surgery at our institution. A total of 128 pediatric patients with 210 incisions used Dermabond(TM) for skin closure. RESULTS: We divided the 128 patients into 3 groups according to type of surgery. Group 1 underwent hydrocelectomy (55 cases, 41.3%), Group 2 underwent orchiopexy (43 cases, 32.3%), Group 3 underwent penoplasty (35 cases, 26.4%). One hundred and twenty eight patients who underwent 133 surgeries in total, with a total of 210 incisions visited our outpatient department postoperatively, and a total of 5 wound complications (2.3%) occurred, but were simple inflammations and no dehiscence was observed. When analyzed according to groups, no wound problems occurred in Group 1 (0/55, 0%), one occurred in Group 2 (1/43, 2.3%) and four cases occurred in Group 3 (4/35, 11.4%) respectively. When re-analyzed according to wound locations, one occurred in an inguinal wound (1/120, 0.83%), none occurred in scrotal wounds (0/55, 0%), and four occurred in penile wounds (4/35, 11.4%). In Group 3, the incidence of penile wounds was significantly increased compared to other groups (P=0.008). All 5 wound problems were inflammatory and healed at an average of 13.8 days (13-15 days) with antibiotic ointment application only. CONCLUSION: Dermabond(TM) is feasible and safe topical skin adhesive alternative to standard skin suture in pediatric urologic surgery. However, further research about its efficacy and safety could be valuable in the future.

Experiences of Renal Transplantation after Correction of Dysfunctional Contracted Bladder / 대한이식학회지

BACKGROUND: There is some controversy about the safety of renal transplantation in patients with an augmentation cystoplasty. The purpose of this study is to assess the early and long-term results of renal transplantation in 6 patients who underwent augmentation cystoplasty to correct bladder dysfunction. METHODS: We retrospectively reviewed the surgical outcome of renal transplants in 6 recipients with augmentation cystoplasty including one ileal conduit. The etiology of bladder dysfunction was neurogenic bladder with detrusor hyperreflexia (4 pediatric patients) and renal tuberculosis (2 adult patients). Augmentation cystoplasty was performed before transplantation in all patients. The bowel segments used in the augmentation cystoplasty included stomach in 2 (including one revision case with ileum), ileum in 3, ileocecal segments in 1, and sigmoid colon in 1 patients. The mean patient's age at transplantation was 25.5 years. Four transplants were from living donors. The donor ureter was anastomosed to ileal conduit in 1, native bladder in 2, and the bowel segment in 3 patients. RESULTS: All transplanted kidneys were functioning at a mean follow-up of 103 months (range 5 to 220). The mean serum creatinine level was 1.0 mg/dl (range 0.7 to 1.8). Acute rejection was diagnosed in protocol biopsy in one patient without graft function deterioration. Four patients admitted for febrile urinary infection during the follow up periods. CONCLUSIONS: Augmentation cystoplasty is a safe and effective method to restore the renal function in patients who have noncompliant bladders. Renal transplantation can be performed safely after augmentation cystoplasty.

Impact of Cardio-Pulmonary and Intraoperative Factors on Occurrence of Cerebral Infarction After Early Surgical Repair of the Ruptured Cerebral Aneurysms

OBJECTIVE: Delayed ischemic deficit or cerebral infarction is the leading cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). The purpose of this study is to reassess the prognostic impact of intraoperative elements, including factors related to surgery and anesthesia, on the development of cerebral infarction in patients with ruptured cerebral aneurysms. METHODS: Variables related to surgery and anesthesia as well as predetermined factors were all evaluated via a retrospective study on 398 consecutive patients who underwent early microsurgery for ruptured cerebral aneurysms in the last 7 years. Patients were dichotomized as following; good clinical grade (Hunt-Hess grade I to III) and poor clinical grade (IV and V). The end-point events were cerebral infarctions and the clinical outcomes were measured at postoperative 6 months. RESULTS: The occurrence of cerebral infarction was eminent when there was an intraoperative rupture, prolonged temporary clipping and retraction time, intraoperative hypotension, or decreased O2 saturation, but there was no statistical significance between the two different clinical groups. Besides the Fisher Grade, multiple logistic regression analyses showed that temporary clipping time, hypotension, and low O2 saturation had odds ratios of 1.574, 3.016, and 1.528, respectively. Cerebral infarction and outcome had a meaningful correlation (gamma=0.147, p=0.038). CONCLUSION: This study results indicate that early surgery for poor grade SAH patients carries a significant risk of ongoing ischemic complication due to the brain's vulnerability or accompanying cardio-pulmonary dysfunction. Thus, these patients should be approached very cautiously to overcome any anticipated intraoperative threat by concerted efforts with neuro-anesthesiologist in point to point manner.

Extravasation from the Distal Anterior Choroidal Artery Aneurysm in Moyamoya Patient during Computed Tomographic Angiography

Three-dimensional computed tomographic angiography (CTA), a representative noninvasive radiologic technique, is being widely used for detecting vascular lesions in specific intracranial bleeding under a certain circumstance (acute nontraumatic subarachnoid hemorrhage). We encountered a case of extravasation of the contrast medium on CTA images that appeared as ribbon-like high-attenuation lesion from an aneurysm at the distal anterior choroidal artery in a young adult moyamoya patient. As CTA is used more frequently, it is imperative to understand such unusual but, potentially lethal image findings to conduct a prompt intervention.

Efficacy and Tolerability of Extended-release Oxybutynin in Children with a Neurogenic Bladder / 대한비뇨기과학회지

PURPOSE: The aim of this study was to investigate the efficacy and tolerability of extended-release oxybutynin(oxybutynin ER) in children with a neurogenic bladder. MATERIALS AND METHODS: Fifty-four patients(21 myelomeningocele and 33 lipomyelomeningocele) with a neurogenic bladder were enrolled in the study. We reviewed the medical records and performed a telephone interview. The treatments were changed from immediate-release oxybutynin (oxybutynin IR) or other anticholinergics to oxybutynin ER from August to December 2006. The mean age of the study patients was 11.1 years (range 4 to 18 years) and the mean body weight was 37.9kg(range 16.2 to 72.0kg). All patients were asked about the effectiveness, side effects and compliance with the medication. The number of voids, volume of urine per void or clean intermittent catheterization(CIC) and number of incontinence episodes were also evaluated. RESULTS: The mean duration of oxybutynin ER treatment was 16.3 weeks (range 7-25 weeks). Twenty-six patients(48.1%) responded they had improvement in voiding symptoms. Among the patients, there was a significant reduction in the number of incontinence episodes(from 3.3 to 1.3, p<0.001) with the change in medications. The number of voids or CIC per 24 hours and the maximum volume of urine per void or CIC did not show a significant change. Another twenty-eight patients(51.9%) responded that the improvements were maintained. Among these patients, there were no significant changes of the medications. Only five patients (9.3%) changed their medication because of the side effects. CONCLUSIONS: The results of this study showed that the extended-release oxybutynin was effective and well tolerated in children with a neurogenic bladder.

Dextranomer/Hyaluronic Acid Copolymer (Deflux(R)) Injection for Vesicoureteral Reflux in Children: the Efficacy and Safety / 대한비뇨기과학회지

PURPOSE: We evaluated the efficacy and safety of Deflux injection for treating vesicoureteral reflux (VUR) in children. MATERIALS AND METHODS: Between January 2004 and May 2006, 49 children (28 boys and 21 girls) with a mean age of 51 months (5-182) underwent Deflux injection. VUR was unilateral in 19 cases (38.8%) and bilateral in 30 (61.2%), affecting 79 ureters. VUR was grades II to V in 26 cases (32.9%), 24 (30.4%), 16 (20.3%), and 4 (5.1%), respectively. Our clinical protocol involved ultrasonography at 6 weeks to evaluate the development of hydronephrosis and the creation of submucosal mound, and VCUG or RIVCU at 3 months to assess the VUR. RESULTS: The median follow-up was 8.0 months (1-22). The cure rate at 3 months by the ureter was 81.6% (88.9% for grade I, 100% for grade II, 79.2% for grade III, 75.0% for grade IV, and 50.0% for grade V) and the cure rate was 84.8% for the total patients (100% for the unilateral cases and 80% for the bilateral cases). There were 16 patients with 1 year of follow-up and the cure rate was 88.5% by the ureter and 87.5% for the total patient. The severity of VUR (p=0.035) and the concomitant voiding dysfunction (p=0.001) were the significant predictors of a successful outcome. One patient complained of gross hematuria resolved within a few days. CONCLUSIONS: Deflux injection was safe and efficacious with a low complication rate. The severity of VUR and the concomitant voiding dysfunction had significant adverse effects on the cure rate.

Aneurysmal Subarachnoid Hemorrhage Associated with Achondroplasia: Case Report / 대한뇌혈관외과학회지

Patients with achondroplasia manifest various neurologic symptoms including megaencephaly, hydrocephalus, and progressive myelopathy or radiculopathy secondary to spinal stenosis. However, only anecdotal postmortem reports proved ruptured aneurysm or vascular malformation as a source of intracranial hemorrhage. We herein report a case of a 26-year-old woman with achondroplasia who underwent uneventful surgical treatment for the aneurysmal subarachnoid hemorrhage. In this literature, we review the pathophysiologic mechanism and emphasize the necessity of considering the possibility of sudden mental deterioration in achondroplastic patient.

Influence of Lamina Terminalis Fenestration on the Occurrence of the Shunt-Dependent Hydrocephalus in Anterior Communicating Artery Aneurysmal Subarachnoid Hemorrhage

Recently, it was reported that fenestration of the lamina terminalis (LT) may reduce the incidence of shunt-dependent hydrocephalus in aneurysmal subarachnoid hemorrhage (SAH). The authors investigated the efficacy of the LT opening on the incidence of shunt-dependent hydrocephalus in the ruptured anterior communicating artery (ACoA) aneurysms. The data of 71-ruptured ACoA aneurysm patients who underwent aneurysmal clipping in acute stage were reviewed retrospectively. Group I (n=36) included the patients with microsurgical fenestration of LT during surgery, Group II (n=35) consisted of patients in whom fenestration of LT was not feasible. The rate of shunt-dependent hydrocephalus was compared between two groups by logistic regression to control for confounding factors. Ventriculo-peritoneal shunts were performed after aneurysmal obliteration in 18 patients (25.4%). The conversion rates from acute hydrocephalus on admission to chronic hydrocephalus in each group were 29.6% (Group I) and 58.8% (Group II), respectively. However, there was no significant correlation between the microsurgical fenestration and the rate of occurrence of shunt-dependent hydrocephalus (p>0.05). Surgeons should carefully decide the concomitant use of LT fenestration during surgery for the ruptured ACoA aneurysms because of the microsurgical fenestration of LT can play a negative role in reducing the incidence of chronic hydrocephalus.

Bladder Dysfunction in Focal Cerebral Ischemia of Rat / 대한비뇨기과학회지

Purpose: The purpose of this study was to evaluate the active contractile properties of detrusor smooth muscle from bladders of cerebral-infarcted rats (CI rats). Materials and Methods: The cerebral infarction was induced in 8 to 9 week-old male Sprague-Dawley rats by occlusion of the left middle cerebral artery. At 2 and 4 weeks after the operation, bladder muscle strips were evaluated for force development in response to electrical field, 5 micrometer carbachol (Cch) and 60mM KCl stimulation using an isometric transducer. The contractile response to field stimulation on the additions of 1micrometer atropine and 5micrometer alpha, beta-methylene ATP (abmATP) were measured, and the contributions of cholinergic and purinergic transmissions determined. Cystometrography (CMG) was also performed in anaesthetized rats. Results: In comparison with sham-operated rats, the CI rats showed a shorter voiding interval, smaller peak voiding pressure, smaller voiding volume and greater residual urine volume on CMG. The CI rats also showed smaller tension at maximum contraction induced by Cch and a quicker response to maximum contraction induced by KCl than the sham operated rats. The CI rats showed time-dependent increases and decreases in the proportions of abmATP-sensitive (purinergic) and atropine-sensitive (cholinergic) components, respectively. Conclusions: CI rats showed changes in detrusor activity, contractility and the proportions of cholinergic and purinergic components. The increase in the purinergic contraction of the detrusor muscle was believed to be related to bladder instability. The results of this study will be useful in explaining detrusor hyperactivity, with impaired contractility (DHIC), in patients with cerebral infarction.

alpha-Adrenoceptor Antagonistic Effect of Palmatine on the Prostatic Urethral Pressure of the Rabbit / 대한비뇨기과학회지

PURPOSE: Palmatine is an isoquinoline alkaloid, with multiple pharmacological actions, including anti-inflammatory activity. The aim of this study was to examine the effect of palmatine on the prostatic urethral pressure in anesthetized rabbit. MATERIALS AND METHODS: 10-week-old male New Zealand White rabbits (3.0-3.5kg) were used in the experiment. After anesthetized with urethane (800mg/kg i.v.), a midline incision was made, and the urinary bladder completely drained. To prevent filling of the bladder, polyethylene tubes were inserted into the bilateral ureters. Using a 3-F MIKRO-TIP catheter transducer positioned in the prostatic urethra, urethral pressure was recorded continuously. To record the blood pressure, the left femoral artery was cannulated with an angiocatheter. After a stabilizing period, phenylephrine (1mug/kg) was intravenously administered two or three times. When the increase in the urethral pressure became stable, palmatine was administered intravenously (0.5-3.0mg/kg), followed by phenylephrine, with no time interval. RESULTS: In the anesthetized rabbits, an intravenous bolus injection of palmatine (0.5-3.0mg/kg) caused no significant change in the resting prostatic urethral pressure (p>0.05), but decreased the blood pressure (p<0.05). After administration of phenylephrine, the urethral pressure increased from 7.5 0.8 mmHg to 26.5 2.6 mmHg, with the difference in the pressure (19.0 3.1 mmHg) being statistically significant (p<0.01). The intravenously administered palmatine (0.5-3.0mg/kg) dose-dependently inhibited the phenylephrine-induced increases in the prostatic urethral pressure and mean blood pressure. The maximal inhibition was obtained when a palmatine dose of 3.0mg/kg was administered, at which point, the decrease in the urethral pressure was 73.1% (p<0.01). CONCLUSIONS: These results indicate that palmatine inhibits the phenylephrine-induced increases in the prostatic urethral pressure and blood pressure in the anesthetized rabbits.

Efficacy and Tolerability of Tolterodine Compared to Oxybutynin in Children with a Neurogenic Bladder / 대한비뇨기과학회지

PURPOSE: The aim of this study was to investigate the efficacy and adverse effects of oral tolterodine compared to oxybutynin in children with a neurogenic bladder. MATERIALS AND METHODS: 16 patients, with persistent daytime or nighttime wetting after oxybutynin medication for the treatment of a neurogenic bladder, were enrolled. All 16 patients had been crossed-over from oxybutynin to tolterodine due to serious side effects or lack of improvement. The mean age was 6.4 years (range 3 to 11), and the mean body weight was 22kg (range 16 to 33). All patients were initially treated with oral tolterodine, 2mg, twice daily. The efficacy of tolterodine was assessed in comparison to oxybutynin, and considered as improved with a greater than 50% reduction in wetting episodes, as stationary with a less than 50% reduction or as increased or aggravated with a greater than 50% increase. The tolerability was also assessed using a questionnaire for adverse events. RESULTS: The mean duration of tolterodine treatment was 193 days (range 14 to 940). After treatment with an initial tolterodine dose of 2mg bid, 5 patients (31%) were improved, 8 (50%) were stationary and 3 (19%) were aggravated. Overall, the initial tolterodine dose showed equal efficacy to that of oxybutynin (p=0.483). Of the 16 patients, side effects developed in 12 (75%) during the oxybutynin treatment, whereas only 2 (13%) developed side effects during the tolterodine treatment (p=0.001). CONCLUSIONS: Compared to oxybutynin, tolterodine was well tolerated in children, allowing greater compliance and offering an equally effective treatment for neurogenic incontinence in children with a neurogenic bladder. Therefore, it seems that tolterodine can be safely and effectively used to replace oxybutynin in children with a neurogenic bladder.

Cerebral Aneurysm and Aortic Coarctation in a 46, XY Female. Is it Causal or Coincidental?

Most vascular disorders tend to affect both the brain and heart, and among them, a clinical syndrome constituting cerebral aneurysm and aortic coarctation(AC) has been well recognized. Persistent hypertensive impact to the cerebral vasculature with developmental anomaly of the neural crest, precursor of ectomenchymal, would be closely associated with development of the cerebral aneurysm in AC. Gonadal steroid hormone, a guardian of the cardiovascular system, has been known for its protective effects on the vascular wall. Gonadal steroid hormone (androgen) insensitivity such as 46, XY female syndrome may increase the risk of hypertention and subsequent vascular anomalies. The authors report on a 46-year-old 46, XY female patient with AC who underwent surgical clipping of the ruptured cerebral aneurysm. Clinical implications and proposed pathogenetic mechanisms of aneurysm in this intersex syndrome are presented and discussed.

Nocturnal Enuresis / 소아과

No abstract available.

Rectus Fascial Sling for Treating Neurogenic Sphincteric Incontinence in Boys with Spina Bifida / 대한비뇨기과학회지

PURPOSE: To evaluate the long-term efficacy and safety of a rectus fascial sling for the treatment of neurogenic sphincteric incontinence in boys with spina bifida. MATERIALS AND METHODS: Between June 1993 and January 2000, 9 boys with myelodysplasia underwent placement of a fascial sling around the bladder neck for the treatment of severe urinary incontinence. Concurrent augmentation cystoplasty and sling cystourethropexy were performed in 8 boys, and the other had been augmented previously. The mean age of the boys was 9.8 years, ranging from 6 to 14 years, and the mean follow-up was 44.4 months, ranging from 1 to 115 months. The continence states and complications were examined after rectus fascial sling placement, and the pre- and post-operative urodynamic findings analyzed. RESULTS: At the last follow up, 4 of the 9 patients had remained completely dry, and one partially dry. Therefore, the overall success rate was 55.5% (5/9). 2 of the 4 who failed to achieve continence still depend on pads, with the other two receiving a finally bladder neck closure. There was no postoperative complication associated with sling procedure itself, and no patient had postoperative upper tract deterioration. Postoperative urodynamic evaluation revealed normal bladder compliance. However, the fascial sling had variable effects on the maximum urethral closure pressure. CONCLUSIONS: It seems that a rectus fascial sling, as a primary treatment of neurogenic sphincteric incontinence, in boys with spina bifida is safe, but its success can not always be guaranteed; therefore, efforts will be required to increase the success rate.

Rectus Fascial Sling for Treating Neurogenic Sphincteric Incontinence in Boys with Spina Bifida / 대한비뇨기과학회지

PURPOSE: To evaluate the long-term efficacy and safety of a rectus fascial sling for the treatment of neurogenic sphincteric incontinence in boys with spina bifida. MATERIALS AND METHODS: Between June 1993 and January 2000, 9 boys with myelodysplasia underwent placement of a fascial sling around the bladder neck for the treatment of severe urinary incontinence. Concurrent augmentation cystoplasty and sling cystourethropexy were performed in 8 boys, and the other had been augmented previously. The mean age of the boys was 9.8 years, ranging from 6 to 14 years, and the mean follow-up was 44.4 months, ranging from 1 to 115 months. The continence states and complications were examined after rectus fascial sling placement, and the pre- and post-operative urodynamic findings analyzed. RESULTS: At the last follow up, 4 of the 9 patients had remained completely dry, and one partially dry. Therefore, the overall success rate was 55.5% (5/9). 2 of the 4 who failed to achieve continence still depend on pads, with the other two receiving a finally bladder neck closure. There was no postoperative complication associated with sling procedure itself, and no patient had postoperative upper tract deterioration. Postoperative urodynamic evaluation revealed normal bladder compliance. However, the fascial sling had variable effects on the maximum urethral closure pressure. CONCLUSIONS: It seems that a rectus fascial sling, as a primary treatment of neurogenic sphincteric incontinence, in boys with spina bifida is safe, but its success can not always be guaranteed; therefore, efforts will be required to increase the success rate.

Bladder Neck Closure for Treating Pediatric Urinary Incontinence / 대한비뇨기과학회지

PURPOSE: Our aim was to evaluate the efficacy of a bladder neck closure (BNC) for the treatment of incontinence in children with a neurogenic bladder. MATERIALS AND METHODS: Between January 1995 and July 2002, 14 children (8 boys and 6 girls) underwent a BNC, with continent diversion. Information on the continence stati and complications following the BNC were evaluated. The mean age at the time of the operation and the follow-up period were 9.7 years, ranging from 6 to 22, and 21 months, respectively. All children suffered from neurogenic incontinence related to spinal bifida. The BNC were performed as primary procedures in 11 children and as secondary procedures in 3. During surgery, the bladder neck was transected and the bladder opening and urethral stump closed in two layers. A Mitrofanoff diversion, with appendix, was performed in all patients. RESULTS: After the BNC, all the patients were completely dry. As for the related complications with the BNC, no leakages or fistulae were seen in any of the patients. Bladder stones were seen in 2 patients, postoperative ileus in 2 and symptomatic urinary tract infection in 1. Stomal complications were seen in 2 patients. One patient each had some pain with the catheterization and mild stomal stenosis, but they all improved with no additional intervention. CONCLUSIONS: With the high success, and low complication, rates, it is concluded that a BNC, in conjunction with bladder augmentation and Mitrofanoff diversion, is highly efficacious in achieving dryness in pediatric urinary incontinence, when used as a primary, as well as a salvage procedure.

Therapeutic Effects of Imipramine and DDAVP in Enuretic Children: A Randomized Prospective Study / 대한비뇨기과학회지

PURPOSE: The therapeutic effects of imipramine and DDAVP in primary monosymptomatic enuretic children were compared using a randomized, prospective study. MATERIALS AND METHODS: The study subjects consisted of 23 children, with a mean age of 7.9 years, complaining of monosymptomatic nocturnal enuresis. Baseline evaluations, at the first visit, included voiding diary, enuresis diary, uroflowmetry, urine osmolality, and urine and serum osmolality after a water deprivation test and electrocardiography. After the administration of medication, the changes in the enuretic episodes and adverse effects were evaluated every month. RESULTS: Sixteen children received medication, and after 2 weeks the drug response rate was 57.1% (4/7) in the imipramine group and 33.3% (3/9) in the DDAVP group. Ten of the 16 children completed the study. After 12 weeks of study, the response rate was 75% (3/4) in the imipramine group and 50% (3/6) in the DDAVP group. There were no significant differences in mean urine osmolalities and functional bladder capacities between the response and no-response groups. During the study, side effects developed in only three of the children in the imipramine group. Of these, one demonstrated tachycardia on a follow-up electrocardiography and another complained of irritability, insomnia, a dry mouth and blurred vision. Subsequently, the two children dropped out due to these side effects. CONCLUSIONS: The imipramine and DDAVP had similar therapeutic effects, but the DDAVP had fewer side effects, and was better tolerated, than the imipramine.

Urodynamic Effect of Oxybutynin Chloride on Bladder Dysfunction in Rats with Focal Cerebral Ischemia

PURPOSE: The purpose of this study was to evaluate the urodynamic effect of oxybutynin chloride on bladder dysfunction in rats with focal cerebral ischemia. MATERIALS AND METHODS: The cerebral infarction of 8 to 9 week-old male Sprague-Dawley rats was induced by occlusion of the left middle cerebral artery. The control groups received sham operation. At 1, 2 and 4 weeks after operation, cystometrogram (CMG) was performed before and after intravesical instillation of 0.5 ml of oxybutynin chloride (0.005 and 0.05 mg/ml) (n=7). RESULTS: The body weight of cerebral-infarcted (CI) rats was smaller than that of sham-operated rats. Compared to sham-operated rats, CI rats showed a shorter voiding interval, smaller micturition pressure, smaller voiding volume and more residual urine. in CMG. After intravesical instillation of oxybutynin, CMG showed dose-dependent increase of voiding interval and functional bladder volume and decrease of peak micturition pressure. The effects of oxybutynin on CI rats were more prominant than that of sham-operated rats. CONCLUSIONS: CI rats showed urinary frequency and decrease of micturition pressure in CMG. The result of this study will be useful for explanation of the detrusor hyperactivity with impaired contractility (DHIC) in patients with cerebral infarction. These results suggest that treatment with intravesical oxybutynin will be an effective alternative treatment of detrusor hyperactivities with cerebral infarction.

3-Dimensional Computed Tomography Angiography in Early Operation for Poor Grade Aneurysms

OBJECTIVE: The authors studied the feasibility of 3-Dimensional computed tomographic angiography(3-D CTA) in early surgery for poor grade patients with aneurysmal subarachnoid hemorrhage(SAH), therefore intended to verify the eligibility of this diagnostic tool in these special clinical settings. METHODS: During the period between July 1997 and December 2000, we studied 31 patients diagnosed as aneurysmal SAH that were classified as the Hunt-Hess grade IV or V and Fisher group III or IV. As the conventional angiography could not be conducted because of the patients' poor clinical conditions, we carried out early surgery on the same day of SAH solely based on the 3-D CTA. We compared the 3-D CTA features with intraoperative findings. RESULTS: Total of 33 aneurysms were found in preoperative 3-D CTA and, of them, all 31 ruptured aneurysms and additional another two unruptured ones were also. Undetected three aneurysms were found in the operative field(2 cases) and postoperative digital subtraction angiography(1 case). The sensitivity of 3-D CTA was 94.7% and specificity was 100%. CONCLUSION: According to our results, 3-D CTA might be sufficient for early surgery of intracranial aneurysms in poor grade SAH patients in urgent conditions.