Analgesic Effect of Methoxyflurane ( Penthrane ) in Burn Dressings / 대한마취과학회지

Methoxyflurane was used as the sole inhalational analgesic in the dressing of 76 burns performed on 10 patients. It was used in air by analgizer(method 1) or analgizer with mask(method 2), or used by the semiclosed circle absorber by Pentec vaporizer(Cyprane) in 100% oxygen with the concentration of mathoxyflurane set at 0.5%(method 3) or at 0.7%(method 4). Comparative study concerning the analgesic action gave the following results: 1. Methoxyflurane through on analgizer(method 1) produced poor to good annalgesic action in burned patients. 2. Analgizer with mask(method 2) produced better analgesic action than analgizer alone. 3. 0.5% setting(method 3) was similar to analgizer with mask(method 2). 4. 0.7% setting(method 4) was produced complete analgesia, amnesia and partial loss of consciousness.

Acute Pulmonar Edema during General Anesthesia / 대한마취과학회지

The authors have experienced, during general anesthesia with methoxyflurane-nitrous oxide- oxygen for explorative laparatomy to perform appendectomy, a case of acute pulmonary edema, which is rare and it's etiology is various. The patient had no specific past or family history and the only predisposing factor was myocardial ischemia caused by cardio-vascular collapse due to severe dehydration. In this case, the authors believed that pre-existing myocardial ischemia, rapid transfusion of 5% dextrose and myocardial depressants (methoxyflurane and d-tubocurarine) were the causative factors. For this reason at least, myocardial depressants should be avoided in severely dehydrated patients. There are many preventive measures and treatments for acute pulmonary edema during general anesthesia. As in this case, we believe that prompt recognition and attention by the anesthesiologists are the most important preventive and therapeutic measures.