A Case of Perforating Lichen Nitidus / 대한피부과학회지

Lichen nitidus is an uncommon, asymptomatic cutaneous eruption. There are many reports of variable subtype of lichen nitidus including of spinous, follicular, vesicular, hemorrhagic, actinic, purpuric, and perforating lichen nitidus. We report a 7-year-old boy who presented with multiple generalized papular eruption that was composed of discrete, flesh colored, 1-2mm sized, glistening, and round shaped papules. The histopathology of the biopsied specimen showed a well-circumscribed dermal infiltrate mainly composed of histiocytes. The overlying epidermis showed atrophy, thinning of granular layer and liquifaction degeneration of basal layer. Transepidermal perforation was observed and eosinophilic amorphous debris was in the channel of the perforation.

A Case of Cutaneous Infection with Mycobacterium Chelonae / 대한피부과학회지

Mycobacterium chelonae is a rapidly growing atypical mycobacteria that can cause both systemic and cutaneous infections as a human pathogen. This saprophyte is ubiquitous in the environment and has been found in water, soil, and dust particles. Clarithromycin is a highly specific drug against M. chelonae. A 53-year-old man had a nodule on the dorsum of his right hand that had developed in 3~4 months. The lesion was a slightly tender 2.0x1.5cm erythematous nodule and had an overlying ruptured pustule. Culture demonstrated atypical mycobacterim, with a polymerase chain reaction (PCR) which confirmed M. chelonae.

A Study of Food Allergy in Patients with Urticaria / 대한피부과학회지

BACKGROUND: Although urticaria is a common skin reaction pattern occuring at some time in the life of approximately 15% to 20% of the population, the exact prevalence of food-induced acute or chronic urticaria remains unknown. OBJECT: The purpose of this study was to determine the prevalence of specific food allergies in patients with urticaria and the potential utility of the skin prick test and CAP-RAST FEIA in the diagnosis of food allergy. METHODS: One hundred patients with urticaria were evaluated for food hypersensitivity by history, eosinophil count, IgE, skin prick test, CAP-RAST FEIA, and open food challenge test (OFCT). RESULTS: 1) The prevalence of specific food allergies in the study population was 35% in history and 8, 18 and 6% in prick, CAP-RAST FEIA and OFCT, respectively. 2) The frequent food allergens were milk, egg, peanut, and wheat. 3) There were no correlations between the duration of urticaria and prick test, CAP-RAST FEIA and OFCT results. 4) Serum IgE levels were correlated with the prick test and CAP-RAST FEIA results, but not the OFCT results. 5) According to the history, 35 patients with urticaria answered that their symptoms were related to food, and of the 35 patients, positive reactions to the prick test and CAP-RAST FEIA were observed in 6 and 10 patients, respectively. Among the other 65 patients who answered that there was no relation between urticaria and food, 2 patients reacted positively to the prick test and 8 patients showed positive result to CAP-RAST FEIA. CONCLUSION: In contrast to high prevalence of food history, the prevalence of food-induced allergic urticaria in Korean patients is only 6%. In contrast to the prick test, CAP-RAST FEIA provides a standardized measurement of food specific IgE antibodies, which may be more useful diagnostic test than prick test to diagnose food allergy in urticaria.

Development and Expression of Recombinant Ara h 1 Fragment Proteins

No abstract available.

A Case of Allergic Contact Dermatitis Due to Topical Minoxidil / 대한피부과학회지

Minoxidil (2, 6-diamino-4-piperidinopyrimidine 1-oxide) is a systemic antihypertensive agent, the topical application of which has been shown to produce hair growth. Topical minoxidil solution (5% minoxidil, propylene glycol, alcohol, water) has generally been well-tolerated, but allergic contact dermatitis has been reported. When allergic contact dermatitis to minoxidil solution is suspected, evaluation of ingredients of minoxidil solution should be performed because allergic contact dermatitis due to propylene glycol in minoxidil solution has been frequently reported. A 34-year-old male presents with a diffuse erythematous patch on the scalp. He has applied minoxidil solution for 7 days due to androgenic alopecia. A Patch test with Korean standard series and the ingredients of used topical agents showed positive reactions to 1%, 2% and 5% minoxidil solution.

Phototherapy of Acne Vulgaris with Low Level Narrow Band Red Light (680 nm) / 대한피부과학회지

BACKGROUND: It has been reported that the phototherapy with blue light (415 nm) or a mixed blue and red light (415 nm and 660 nm) is effective in the treatment of acne vulgaris. however, the effects of red light on acne vulgaris have not been investigated. OBJECT: To examine the effects of red light (680 nm) on patients with moderate acne vulgaris. METHODS: Patients treated their skin by themselves, using portable light source (680 nm), and irradiation was performed for 7 minute twice daily. Each patient was evaluated every 2 weeks with Burton scale and the numbers of papules and pustules. After 6 weeks, the degrees of satisfaction of patients and physicians were assessed. RESULT: Therapy with red light significantly decreased the numbers of papules and pustules (p<0.01). The numbers of satisfied patients and physicians at the end of treatment were 59 (83.1%) and 56 (78.9%) respectively. Side effect was not reported, except only one patient complained of headache. CONCLUSION: Phototherapy with red light (680 nm) was effective and safe treatment for patients with acne vulgaris.

A Case of Tuberous Xanthoma in Early Childhood / 대한피부과학회지

We report a 6-year-old male with primary hypercholesterolemia who had tuberous xanthoma. Yellowish nodules first appeared on the knees 3 years ago and gradually increased in size and number and also occurred on the left elbow. The laboratory findings showed markedly increased serum cholesterol and slightly increased triglyceride. Serum lipoprotein electrophoresis showed a marked increase in beta-fraction, suggesting type II hyperlipoproteinemia. Histopathology showed many aggregates of foam cells in the dermis and subcutaneous fat.

An Evaluation of Cockroach Allergies in Atopic Dermatitis

BACKGROUND: Atopic dermatitis (AD) is primarily influenced by environmental factors including exposure to pollutants and indoor allergens (particularly, house dust mites). Al-though house dust mite antigens are the most prevalent components of indoor allergens in Korea, cockroaches also can be considered to act as an important allergen. OBJECT: This study was done to evaluate the differences in three different atopic patch test (APT) techniques, and the relationship between APT and skin prick test, total IgE, and specific serum IgE level using cockroach allergen. Methods: We performed patch test in 57 patients with AD and 30 normal controls on clinically lesional and normal appearing skin with German cockroach (GC) allergens (extract, as is) in three different techniques (standard, scratch, DMSO). Reactions were evaluated after 48hours, and compared with the results of skin prick test, total and specific IgE levels. Detailed atopy history and severity scoring were taken. RESULTS: In the GC (whole body) prick test positive group, there was 1263.02 IU/ml of total IgE, and this amount was significantly higher than GC (whole body) prick test negative group who had 549.46 IU/ml (P0.05). There was no significant relationship between the positive reactions to patch test and prick test to Ext and As is antigen. The APT results showed no significant concordances with skin prick test and RAST for cockroach antigens. CONCLUSIONS: APT seems to be a different dimension of atopic skin inflammation and may pro-vide further diagnostic information in addition to a patient's history, skin prick test, and RAST results.

A Case of Allergic Contact Dermatitis Due to Benzethonium Chloride / 대한피부과학회지

Benzethonium chloride is quaternary ammonium compounds, which may cross-react with benzalkonium chloride. It has been used in the treatment of burns, ulcers, wounds, and infected dermatoses and also present in many cosmetics, deodorants, mouthwashes, dentifrices, lozenges, and ophthalmic preparations. Cetostearyl alcohol is used as emulsifiers and can be considered as preservatives. A 19-year-old female presented with well-demarcated adult-fist sized dark-reddish patch on the left shin. She had applied Senepul(R) (disinfectant solution) 3 months ago due to scratching wound and applied Travogen(R). Patch test with Korean standard series and the ingredients of used topical agents showed positive reactions to benzethonium chloride and cetostearyl alcohol.

Two Cases of Mushroom Intolerance / 대한피부과학회지

Shiitake (Lentinus edodes) is nowadays the second most commonly produced edible mushroom in the world. Two patients complained of severe itching and showed widespread disseminated very small erythematous papule and characteristic linear grouped erythematous papules after scratching (Kobner phenomenon). Here we report two cases of mushroom intolerance which developed after ingestion of boiled or cooked shiitake mushrooms.

A Case of Malignant Fibrous Histiocytoma / 대한피부과학회지

Malignant fibrous histiocytoma (MFH) is a pleomorphic sarcoma which most frequently arises in the soft tissue. About two-thirds of the tumors are located within skeletal muscle; relatively few cases have been reported arising in the skin. The micromorphology of the tumor is characterized by storiform histiocyte-like cells, malignant giant cells and bizzare mitoses. We report here a case of cutaneous MFH developed in xeroderma pigmentosum occurred in a middle-aged man.

A Case of Congenital Trichofolliculoma / 대한피부과학회지

Trichofolliculoma is a benign, highly structured adenoma of the pilosebaceous unit, usually occuring on the face or scalp as 0.5 to 1.0 cm solitary papule in persons past middle age. This benign neoplasm rarely occurs prior to early adult life or neonate. We report a case of congenital trichofolliculoma in a 13-year-old girl who had had a single asymptomatic mass on the posterior aspect of right auricle since birth.