RESUMO
Two grams each of five traditional medicine formulations (TMF), TMF-06, TMF-24, TMF-25, TMF-35A and TMF-35B- orally administered with 150 ml of betel leaf preparation, had underwent a clinical trial of antipyretic efficacy on a total of 315 TAB-induced pyrexial Burmese volunteers. Both positive control of acetyl sallicylate 600 mg orally and negative control of no drug treatment were included. The trial design was performed on a single (observer) blind basis. Effectiveness of the agents at the peak of induced pyrexia were observed for three hours. Only TMF-06 possessed the antipyretic efficacy (78-88 per cent) as could be observed in 87-96 per cent of responders, in comparison to those of the acetyl salicylate. Nevertheless, TMF-24 and TMF-35B showed a lesser antipyretic activity. Therefore, TMF-06 was found to be the most recommendable antipyretics to be used at indigenous medicine centres.