RESUMO
BACKGROUND: Although it is important to be aware of the clinicopathological features of pseudolymphoma of the skin to avoid misdiagnosis, there are few comprehensive studies on this disease entity in the Korean dermatologic literature. OBJECTIVE: The purpose of this study was to evaluate the clinical and histopathological features of pseudolymphoma. METHODS: We reviewed the medical records, photographs and histopathological slides of 17 patients, who had been diagnosed with cutaneous pseudolymphoma, between March 2001 and August 2011. RESULTS: The ratio of males to females was 1:3.3, and the mean age of onset was 47.8 years old. Ten patients (59%) had no symptom and the most commonly involved site was the head and neck (59%). Ten patients (59%) had a solitary lesion. Nobody had a family history or past history of pseudolymphoma or lymphoma. Of the 17 cases, 16 (94%) were idiopathic. The common microscopic feature of pseudolymphoma was diffuse and dense lymphocytic infiltration in the reticular dermis. In the immunohistochemical staining of 15 cases (88%), the infiltrating cells were positive for both B cell and T cell marker. The treatment included intralesional steroid injection, systemic steroids and excision. An average follow-up period was 38.4 months (from 2 to 107 months) for 13 patients. During this period, no recurrence or malignant transformation was observed in these patients. CONCLUSION: Our findings demonstrate that cutaneous pseudolymphoma is most common in middle-aged female, and it has a good response to steroid treatment or simple excision, without malignant transformation.
Assuntos
Feminino , Humanos , Masculino , Idade de Início , Derme , Erros de Diagnóstico , Seguimentos , Cabeça , Linfoma , Prontuários Médicos , Pescoço , Pseudolinfoma , Recidiva , Pele , EsteroidesRESUMO
Localized scleroderma is a connective tissue disorder characterized by thickening and fibrosis of the skin due to excessive collagen deposition in the dermis. Dystrophic calcinosis occurs when calcium is deposited in the previously damaged skin tissue, and calcium and phosphorous levels in the blood are within normal limits. It occurs secondary to connective tissue disease, infection, inflammatory processes, chronic venous stasis, cutaneous neoplasm, and trauma. We report a rare case of dystrophic calcinosis cutis with transepidermal elimination secondary to localized scleroderma.
Assuntos
Calcinose , Cálcio , Colágeno , Tecido Conjuntivo , Doenças do Tecido Conjuntivo , Derme , Fibrose , Esclerodermia Localizada , PeleRESUMO
Skin cancers usually occur on the face and so successive cutaneous reconstruction after surgery is very important for the patients' quality of life. Cutaneous reconstruction is especially difficult when the defects after surgery involve the nasolabial fold. The nasolabial folds run from each side of the nose to the corners of the mouth, separating the cheeks from the upper lip. This area has complex contours, unique skin color and texture and the limited availability of mobile adjacent skin. We reconstructed such a defect after Mohs micrographic surgery for basal cell carcinoma of the nasolabial fold area, and we used a subcutaneous island pedicle flap and periosteal suspension suture. Herein we report on the details with the pictures, and we discuss the cosmetic effect and limitations of this method.
Assuntos
Carcinoma Basocelular , Bochecha , Cosméticos , Lábio , Cirurgia de Mohs , Boca , Sulco Nasogeniano , Nariz , Qualidade de Vida , Pele , Neoplasias Cutâneas , SuturasRESUMO
Desmoid tumors are uncommon benign neoplasm of the fibroblasts. They occur rarely in the general population, but they are comparatively common in patients with familial polyposis coli with or without other elements of Gardner's syndrome. Herein, we report a 16-year-old woman with Gardner's syndrome complicated by desmoid tumors on the right subscapular area.
Assuntos
Adolescente , Feminino , Humanos , Polipose Adenomatosa do Colo , Fibroblastos , Fibromatose Agressiva , Síndrome de GardnerRESUMO
BACKGROUND: Viral warts are benign epithelial proliferations induced by the human papillomavirus (HPV) and they affect 7~10% of the population. Some warts such as periungual warts are resistant to various treatment modalities, including cryotherapy, surgical excision, carbon dioxide laser therapy and immune therapy. Thus, some studies have reported that pulsed dye laser has been effectively used for treating recalcitrant warts. OBJECTIVE: The purpose of this study was to evaluate the therapeutic response and safety of pulsed dye laser using high fluence for the treatment of periungual warts. METHODS: 66 periungual warts on 28 patients were treated with pulsed dye laser. The treatment parameters were a spot size of 5.0 mm, a pulse duration of 0.45~1.5 ms and a fluence of 14.0~15.0 J/cm2. The warts were evaluated at 2~3 week intervals to assess the clearance rate and side effects. RESULTS: Complete clearance was achieved for 47 out of 66 periungual warts (71.2%). The average number of treatment sessions was 2 (range: 1~6). After the first session, complete clearance was achieved for 24 out of 66 warts (36.4%). No significant side effects were observed except for pain during and after the procedure. During a median follow up period of 7 months (range: 3~15 months), 10 periungual warts on 3 patients recurred. CONCLUSION: Pulsed dye laser using high fluence could be used as a safe and successful treatment for recalcitrant periungual warts.
Assuntos
Humanos , Crioterapia , Seguimentos , Lasers de Corante , Lasers de Gás , VerrugasRESUMO
Clear cell hidradenoma (CCH) is a relatively rare benign tumor that shows differentiation toward the structure of an eccrine sweat gland. The tumor masses are composed of solid areas and tubular lamina. Cystic spaces are often present and on rare occasions they can be of considerable size. The cystic variant of CCH is referred as solid cystic hidradenoma. We present a case of cystic clear cell hidradenoma that occurred on the abdomen in a 42-year-old man. The tumor contained a solid tumor of CCH encircled by a large cystic space, and the cystic space was lined by two to four layers of epithelium.
Assuntos
Adulto , Humanos , Abdome , Acrospiroma , Epitélio , Glândulas SudoríparasRESUMO
Zinc deficiency is characterized by acrodermatitis enteropathica like eruption such as periorificial dermatitis, diarrhea and mental irritability. This syndrome occurs due to decreased supplementation, increased consumption or decreased bowel absorption of zinc. We report here on a case of acquired zinc deficiency in a patient who was receiving total parenteral nutrition due to ischemic colitis. She showed denuded patches on the perinasal, perioral and perineal area and tense bullae on both hands. She was suffering from diarrhea and mental irritability. Her blood zinc level was 4.9microng/dl. Subsequent intravenous zinc supplementation cleared up her clinical manifestations.
Assuntos
Humanos , Absorção , Acrodermatite , Vesícula , Colite Isquêmica , Dermatite , Diarreia , Mãos , Nutrição Parenteral Total , Estresse Psicológico , Estimulação Elétrica Nervosa Transcutânea , ZincoRESUMO
Becker nevus syndrome is a phenotype characterized by the presence of a Becker nevus in association with unilateral hypoplasia of the breast or other cutaneous, muscular or skeletal defects. We report an interesting case of Becker's nevus syndrome associated with fibrous dysplasia of the sphenoid bone, tooth abnormalities and facial asymmetry.
Assuntos
Mama , Nevo , Fenótipo , Neoplasias Cutâneas , Osso Esfenoide , Dente , Anormalidades DentáriasRESUMO
Milker's nodule is a harmless skin lesion that's caused by the paravaccinia virus (also called pseudocowpox virus), which is a member of the genus Parapoxviridae. It occurs worldwide, but it is prevalent only in individuals who are in close contact with cattle. We report here on a woman who presented with a dusky purpuric center surrounded by a white or gray ring and an outer red halo on the back of the right hand. Histologically, intracytoplasmic inclusion bodies were evident in the upper epidermis, and these revealed cylindrical virus particles on electron microscopy. Parapoxvirus was identified by polymerase chain reaction with using pan-parapoxvirus primer 1 (PPP-1) and PPP-4.
Assuntos
Animais , Bovinos , Feminino , Humanos , Epiderme , Mãos , Corpos de Inclusão , Microscopia Eletrônica , Parapoxvirus , Reação em Cadeia da Polimerase , Vírus da Pseudovaríola das Vacas , Pele , VírionRESUMO
Renal cell carcinoma (RCC) is well known for its frequent metastasis and particularly to the lungs, liver, bones and brain, but metastasis to the skin is rare. We report here on a case of metastatic RCC in a 73-year-old man who presented with a 1.5 cm sized, moist, beefy-red and exophytic nodule on the scalp. The lesion had grown rapidly for 2 months and it clinically mimicked granuloma pyogenicum. A skin biopsy revealed a solid mass composed of clear cells with clear cytoplasm and oval hyperchromatic nuclei, and they were arranged in an alveolar pattern. As skin metastasis from renal cell carcinoma signals widespread systemic metastasis and a poor prognosis, clinicians should conduct a careful inspection of the skin of a patient with RCC and they should also have a high index of suspicion for finding a primary internal organ malignancy in the RCC patients who present with a skin lesion.
Assuntos
Idoso , Humanos , Biópsia , Encéfalo , Carcinoma de Células Renais , Citoplasma , Granuloma , Granuloma Piogênico , Fígado , Pulmão , Metástase Neoplásica , Prognóstico , Couro Cabeludo , PeleRESUMO
The dermal melanocytoses include a variety of pigment lesions that are formed from the aberrant development of the neural crest-derived melanocytes as they migrate through the dermis during embryogenesis. Neurocristic cutaneous hamartomas is one type of the dermal melanocytoses, which contain dermal melanocytic, neurosustentacular and fibrogenic components and can undergo malignant transformation. We describe a case of dermal melanocytosis showing features of neurocristic cutaneous hamartoma.