Correlation between Genetic Polymorphism of CYP2D6 and CYP1A1 and Susceptibility of Renal Cell Carcinoma in Korean / 대한암학회지

PURPOSE: Many of the enzymes handling environmental factors are polymorphic and may confer variable susceptibility to renal cell carcinoma (RCC). Among those, the author studied genetic polymorphisms of CYP2D6 (B & T) and CYP1A1 in RCCs and controls in Korean. MATERIALS AND METHODS: Using 132 RCCs and 94 controls, first PCR products were obtained in 104 RCCs and 94 controls with CYP2D6, and 74 RCCs and 56 controls with CYP1A1. Res triction enzyme - BstN I/EcoN I for CYP2D6 (B & T), and NCo I for CYP1A1-digestion was followed to analyze constitutive DNA. RESULTS: In both RCCs and controls, no mutant allele of CYP2D6 (B & T) was detected and the susceptibility for occurrence of RCC was unable to evaluate. With CYP1A1 RFLP, homozy gous wild type (WW) was seen in 68 (52.3%; 37 RCCs, 31 controls), heterozygous mutant type (WM) in 54 (41.5%; 32 RCCs, 22 controls) and homozygous mutant type (MM) in 8 (6.2%; 5 RCCs, 3 controls). The odds ratios (95% CI) of RCC susceptibility for CYP1A1 genotype were 1.15 for WM and 1.36 for MM. Even though not significant statistically, higher tendency in MM presented. CONCLUSION: There is no association between susceptibility for the occurrence of RCC and genetic polymorphism of CYP2D6 (B & T) and CYP1A1.

Experiences of the Vesico-Psoas Hitch Procedure for Extensive Lower Ureteral Stricture / 대한비뇨기과학회지

Three patients have successfully undergone ureteroneoystostomy with submucosal tunneling as an antirefluxing measure using vesico-psoas hitch procedure for extensive postoperative stricture of the lower ureter. Postoperatively, none of the patients has developed ureterovesical stenosis, and functional capacity of the bladder has been well preserved despite of extensive mobilization. In one patient reflux has occurred through the ureteral orifice of the opposite side. Since the technique of vesico-psoas hitch procedure is simply to mobilize the bladder and to fix its posterolateral corner to the psoas muscle, we believe that it provides a safer alternative to more complicated and potentially dangerous procedures.

Primary Psoas Abscess: A Case Report / 대한비뇨기과학회지

We report a case of primary psoas abscess which is a relatively rare condition. The etiology of this disease remain uncertain, but the hematogeneous seeding have been proposed as initiating factors. The clinical presentation and review of literature are discussed.

The Prognosis of Pyeloplasty for Ureteropelvic Junction Stricture / 대한비뇨기과학회지

Restoration of functional and anatomic changes of kidney in UPJ stricture is one of most important subjects in urology. A clinical observation was made on the 28 cases (29 kidneys) of pyeloplasties for UPJ stricture from Jan. 1976 to Dec. 1981. Of them 20 cases (21 kidneys) were followed up for more than 6 months postoperatively. The following results were obtained; 1. The patients in this series were 22 males and 6 females, and 11 children and 17 adults. The left side was 3 times more frequently affected than the right. They symptoms on admission were mostly flank pain, palpable mass, and etc. 2. Preoperative status of UPJ was; UPJ stricture alone in 20, UPJ stricture with aberrant vessel in 4, UPJ stricture with stone in 3, and UPJ stricture with vesicoureteral reflux in 1 case. 3. Preoperative grade of hydronephrosis was closely related to each other in the functional and anatomic aspects of kidney. In general, children showed relatively more advanced hydronephrosis than adults and the degree of improvement of hydronephrosis postoperatively was similar to each other. 4. Anderson Hynes' method of pyeloplasty in most cases (20 kidneys) and simple pyeloureterostomy in 9 kidneys were performed, and results between both operations showed no difference. But Anderson Hynes' method was more effective in marked hydronephrosis such as giant hydronephrosis and simple pyeloureterostomy in mild hydronephrosis. 5. In cases in which UTI was present preoperatively, postoperative UTI tended more to persist than in those not complicated with preoperative UTI, and in both sides postoperative UTI mostly persisted for 2 months and disappeared within 6 months. 6. The period of nephrostomy and ureteral stent was not directly related to postoperative results, but nephrostomy without ureteral stent relatively showed good results. 7. Postoperative complication was UTI in 2, re-do pyeloplasty in 1 and secondary nephrectomy in 1 case. 8. Improvement Of hydronephrosis continued for about a year after operation. It is recommended that more careful attention should be paid for the first year and be continued to watch for consecutive 2 years.

Priapism : Report of Two Cases / 대한비뇨기과학회지

Priapism is a condition of prolonged erection, unassociated with sexual stimulation, which is usually painful We experienced two cases of idiopathic priapism, the one was cured by the corporal irrigation with normal saline containing heparin through the glans tip and the other by the corpora cavernosa-saphenous vein shunt. Postoperatively potency in these two cases was obtained.

A Case of Giant Simple Renal Cyst / 대한비뇨기과학회지

Recently with the development of several diagnostic methods, incidence of renal cyst is progressively increased. Renal cysts are usually asymptomatic, produce no harm to the kidney and require no treatment once diagnosed. Herein was reported observation on a cases of giant simple renal cyst which revealed a palpable mass on the right upper quadrant in a 55 years old male. This case was definitely diagnosed by the physical examination, intravenous pyelography, ultrasonography, renal cystography, and selective renal angiography, and the cystic cavity which bad pin point sized communication with middle calyx of right kidney contained about 1300cc of clear yellowish fluid, The unroofing of cyst was performed, and also calycorrhaphy of middle calyx of right kidney was done.